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Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additionally we are shipping SEMA3E Antibodies (102) and SEMA3E Kits (17) and many more products for this protein.
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Sema3E could be considered an essential regulatory mediator involved in modulation of neutrophil migration throughout the course of neutrophilic inflammation.
Results show high expression level of SEMA3E which correlated with lymph node involvement, metastatic progression and a significant association with poor prognosis in gastric cancer patients. Also, in vitro studies reveal that SEMA3E caused cell proliferation and anchorage-independent cell growth in the intestinal type of gastric cancer.
suggested that miR (show MLXIP Proteins)-4282 is a tumor suppressor in colorectal carcinoma cells and exerted its inhibitory effect on the tumor cells through targeting Sema3E by inhibiting Sema3E translation or enhancing Sema3E mRNA degradation
This study aims to investigate whether the Tribbles 3 (show TRIB3 Proteins) Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis.
This study suggests that NRP1 (show NELL1 Proteins) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (show CYP11A1 Proteins))of the tongue, whereas the expression of VEGFC (show VEGFC Proteins), VEGFR3 (show FLT4 Proteins), CCR7 (show CCR7 Proteins), and SEMA3E are nonindependent predictive factors
Authors suggest that silencing of Sema3E contributes to the pathogenesis of gastric cancer.
Findings suggest that Plexin-D1 (show PLXND1 Proteins)/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc (show CYP11A1 Proteins)) endothelium.
Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F (show SEMA3F Proteins).
these results identify SEMA3E as an essential gene for GnRH (show GNRH1 Proteins) neuron development, uncover a neurotrophic function for SEMA3E in the developing brain
The ANGPTL4 may be a candidate target in DME treatment and a biomarker of ischemic-induced retinopathy, including diabetic retinopathy.
that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis
The data indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways. More important, replenishment of Sema3E by intranasal administration of exogenous Sema3E protects mice from allergic asthma by reducing eosinophilic inflammation, serum IgE level, and T helper cell 2/T helper cell 17 cytokine response.
findings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events and suggest that targeting this molecule could be a novel approach to treat allergic asthma.
Our results demonstrate that sema3e/plexin D1 (show PLXND1 Proteins) modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues.
Sema3E is a natural negative regulator of the migration of PlexinD1-positive Cajal-Retzius (CR) cells originating in the cortical hem. Sema3E/PlexinD1 signaling controls the motogenic potential of CR cells in vitro and in vivo.
Our results indicate that Sema3e, secreted by damaged hepatocytes, affects sinusoidal regeneration in a paracrine manner during liver regeneration
Semaphorin 3d (show SEMA3D Proteins) requires neuropilin 1 (show NRP1 Proteins) or PI3K/Akt (show AKT1 Proteins), whereas semaphorin 3e requires plexin D1 (show PLXND1 Proteins) in directing endothelial motility.
Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools.
Sema3E acts as a chemoattractant for macrophages, with p53 (show TP53 Proteins)-induced upregulation of Sema3E expression provoking adipose tissue inflammation and systemic insulin (show INS Proteins) resistance in association with dietary obesity.
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.
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