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SEMA5B encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. Additionally we are shipping SEMA5B Antibodies (35) and many more products for this protein.
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SEMA5B could possibly serve as a candidate gene for alterations associated with asbestos exposure.
Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons.
Sema5A (show SEMA5A Proteins) and Sema5B inhibit retinal neurite outgrowth through PlexinA1 (show PLXNA1 Proteins) and PlexinA3 (show PLXNA3 Proteins) receptors both in vitro and in vivo.
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene.
, sema G
, semaphorin 5B