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STK10 encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Additionally we are shipping Serine/Threonine Kinase 10 Proteins (7) and many more products for this protein.
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Human Polyclonal STK10 Primary Antibody for ELISA, WB - ABIN1452087
Kuramochi, Matsuda, Okamoto, Kitamura, Yonekawa, Karasuyama: Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. in Immunogenetics 1999
Show all 2 references for ABIN1452087
Human Polyclonal STK10 Primary Antibody for WB - ABIN372704
Erikson, Haystead, Qian, Maller: A feedback loop in the polo-like kinase activation pathway. in The Journal of biological chemistry 2004
Show all 2 references for ABIN372704
Human Polyclonal STK10 Primary Antibody for ELISA - ABIN1999179
Walter, Cutler, Martinez, Gishizky, Hill: Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. in The Journal of biological chemistry 2003
STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.
It was shown that lymphocyte-oriented and STE20 kinase (show SLK Antibodies) were sufficient to restrict ezrin (show EZR Antibodies) function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Opposing roles of serine/threonine kinases MEKK1 (show MAP3K1 Antibodies) and LOK in regulating the CD28 (show CD28 Antibodies) responsive element in T-cells
Stk10 is a novel polo-like kinase (show PLK1 Antibodies) kinase that cooperates with hSlk (show SLK Antibodies) to regulate Plk1 (show PLK1 Antibodies) function in human cells
These studies identify a new ERM (show ETV5 Antibodies) kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin (show MSN Antibodies) phosphorylation in regulating cell shape and motility.
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
, serine/threonine-protein kinase 10
, polo-like kinase kinase 1
, serine/threonine-protein kinase 10-A
, germ cell kinase 1