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Part of pre- and post-splicing multiprotein mRNP complexes. Additionally we are shipping SRRM1 Kits (3) and SRRM1 Proteins (3) and many more products for this protein.
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1H, 13C, and 15N resonance assignments and secondary structure of the PWI (show WRB Antibodies) domain from SRm160 was determined using reduced dimensionality NMR.
Proto-oncoprotein TLS/FUS (show FUS Antibodies) is associated to the nuclear matrix and complexed with splicing factors PTB (show PTBP1 Antibodies), SRm160, and SR proteins and plays a role in spliceosome assembly
two contiguous sequences that independently target SRm160 to nuclear matrix sites at splicing speckled domains: amino acids 300-350 and 351-688
Data show that SRm160, a splicing coactivator and component of the exon junction complex (EJC) involved in RNA export, has an adenosine triphosphate (ATP)-dependent mobility.
found that the majority of proteins identified in SRm160-containing complexes are associated with pre-mRNA processing (show PRPF39 Antibodies). Interestingly, SRm160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion
SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner.
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates (By similarity).
SR-related nuclear matrix protein of 160 kDa
, Ser/Arg-related nuclear matrix protein
, serine/arginine repetitive matrix protein 1
, plenty-of-prolines 101