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Serine/arginine Repetitive Matrix 4 Proteins (SRRM4)

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009].. Additionally we are shipping SRRM4 Antibodies (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRRM4 84530 A7MD48
SRRM4 68955 Q8BKA3
Rat SRRM4 SRRM4 498189  
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Top SRRM4 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

SRRM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Serine/arginine Repetitive Matrix 4 (SRRM4) Interaction Partners

Human Serine/arginine Repetitive Matrix 4 (SRRM4) interaction partners

  1. The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC.

  2. Neural microexons are regulated by the neuronal-specific splicing factor (show SLU7 Proteins) nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100.

  3. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC

Mouse (Murine) Serine/arginine Repetitive Matrix 4 (SRRM4) interaction partners

  1. Loss of nSR100 impairs development of the central and peripheral nervous systems in part by disrupting neurite outgrowth, cortical layering in the forebrain, and axon guidance in the corpus callosum

  2. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC

  3. required for the continued survival and differentiation of inner and vestibular hair cells past a set point in their development

  4. Srrm4 function is critical in the hearing and balance organs, but not in all neural tissues. Srrm4 is the first alternative-splicing regulator (show PTBP2 Proteins) to be associated with hearing. Analysis of bv mice provides exon-level insights into hair-cell development.

  5. role for nSR100 in the inhibition of REST activity, blocking nSR100 expression in the developing mouse brain impairs neurogenesis

  6. Study identified the neural-specific SR-related protein of 100 kDa (nSR100)& shows that nSR100 regulates an extensive network of brain-specific (show CALY Proteins) alternative exons enriched in genes that function in neural cell differentiation.

SRRM4 Protein Profile

Protein Summary

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009

Gene names and symbols associated with SRRM4

  • serine/arginine repetitive matrix 4 (SRRM4)
  • serine/arginine repetitive matrix 4 (Srrm4)
  • serine/arginine repetitive matrix 4 (srrm4)
  • 1500001A10Rik protein
  • B230202K19Rik protein
  • im:7136231 protein
  • KIAA1853 protein
  • mKIAA1853 protein
  • MU-MB-2.76 protein
  • nSR100 protein
  • RGD1560213 protein
  • si:dkey-1k23.1 protein
  • SRRM2C protein
  • ZnSR100 protein

Protein level used designations for SRRM4

medulloblastoma antigen MU-MB-2.76 , neural-specific SR-related protein of 100 kDa , neural-specific serine/arginine repetitive splicing factor of 100 kDa , serine/arginine repetitive matrix protein 4 , KIAA1853 protein-like , serine/arginine repetitive matrix 2C , serine/arginine repetitive matrix 4 , Neural-specific serine/arginine repetitive splicing factor of 100 kDa

GENE ID SPECIES
84530 Homo sapiens
416989 Gallus gallus
611405 Canis lupus familiaris
614115 Bos taurus
68955 Mus musculus
498189 Rattus norvegicus
796574 Danio rerio
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