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The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Additionally we are shipping STRAP Kits (7) and STRAP Proteins (5) and many more products for this protein.
Showing 10 out of 54 products:
Cow (Bovine) Polyclonal STRAP Primary Antibody for IHC, WB - ABIN2783200
Seong, Jung, Choi, Kim, Ha: Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. in The Journal of biological chemistry 2005
Human Polyclonal STRAP Primary Antibody for EIA, WB - ABIN453401
Adams, Graham, Jansson, Coutts, Edelmann, Smith, Kessler, La Thangue: ATM and Chk2 kinase target the p53 cofactor Strap. in EMBO reports 2008
Human Monoclonal STRAP Primary Antibody for IF, WB - ABIN968485
Datta, Chytil, Gorska, Moses: Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. in The Journal of biological chemistry 1999
MAWD and MAWBP (show PBLD Antibodies) were downregulated and associated with the differentiation grade in GC tissues.
STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase.
Strap augments the apoptotic effects of mitochondrial p53 (show TP53 Antibodies).
Coexpression of MAWBP (show PBLD Antibodies) and MAWD inhibited epithelial mesenchymal transformation, and EMT (show ITK Antibodies)-aided malignant cell progression was suppressed in gastric cancer.
Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I (show COL1A2 Antibodies)) mRNAs.
both of the TPR and OB-fold domains localize to the chromatin of p53 (show TP53 Antibodies) target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 (show TP53 Antibodies) response
STRAP protein decreases ubiquitination of intracellular domain of Notch3 (show NOTCH3 Antibodies) and may help to stabilize it.
B-MYB (show MYBL2 Antibodies) acts as a positive regulator of STRAP
gonucleotide pulldown identified STRAP (serine/threonine kinase receptor-associated protein) as a further protein recruited to the MMP28 (show MMP28 Antibodies) promoter and acting functionally with Sp1 (show PSG1 Antibodies).
STRAP can act as a negative regulator of ASK1 (show MAP3K5 Antibodies).
STRAP Ser (show SIGLEC1 Antibodies)(188) phosphorylation in the liver is tightly associated with cell death and proliferation through ASK1 (show MAP3K5 Antibodies), TGF-beta (show TGFB1 Antibodies), p53 (show TP53 Antibodies), and PI3K/PDK1 (show PDPK1 Antibodies) pathways, resulting in apoptotic cell death.
both of the TPR (show GRID2 Antibodies) and OB-fold domains localize to the chromatin of p53 (show TP53 Antibodies) target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 (show TP53 Antibodies) response
STRAP regulates c-Jun (show JUN Antibodies) stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun (show JUN Antibodies).
Gemin8 (show GEMIN8 Antibodies) has an essential role in the proper structural organization of the SMN (show STMN1 Antibodies) complex and the involvement of the heteromeric subunit containing Gemin6 (show GEMIN6 Antibodies), Gemin7 (show GEMIN7 Antibodies), Gemin8 (show GEMIN8 Antibodies), and Unrip in the recruitment of Sm proteins to the snRNP (show LSM2 Antibodies) assembly pathway
NM23-H1 (show NME1 Antibodies) and its interacting partner STRAP physically interact with p53 (show TP53 Antibodies) and positively regulate its functions, including p53 (show TP53 Antibodies)-induced apoptosis and cell cycle arrest
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).
serine-threonine kinase receptor-associated protein
, MAP activator with WD repeats
, WD-40 repeat protein PT-WD
, unr-interacting protein
, UNR-interacting protein