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The product of MST4 is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. Additionally we are shipping Serine/threonine-Protein Kinase MST4 Antibodies (66) and and many more products for this protein.
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Human MST4 Protein expressed in Baculovirus infected Insect Cells - ABIN2003193
Lin, Chen, Fang, Robinson, Kung, Shih: MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. in Oncogene 2001
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Findings reveal a mechanism by which TRAF6 (show TRAF6 Proteins) is regulated and highlight a role for MST4 in limiting inflammatory responses.
these data identify the MST4 kinase as a novel candidate to mediate human pituitary tumorigenesis in a hypoxic environment and position it as a potential therapeutic target.
Our results suggest that MST4, STK25 (show STK25 Proteins) and PDCD10 (show PDCD10 Proteins) are upregulated in prostate cancer and may play roles in prostate tumorigenesis. MST4 may be a helpful marker for identifying prostate cancer.
This study describes the key role of MST4 in facilitating the epithelial-mesenchymal transition process in hepatocellular carcinoma
Mutation of this residue was sufficient to switch the phosphorylation site preference for multiple kinases, including the serine-specific kinase PAK4 (show PAK4 Proteins) and the threonine-specific kinase MST4.
CCM3 (show PDCD10 Proteins) forms a stable complex with MST4 in vivo to promote cell proliferation and migration synergistically in a manner dependent on MST4 kinase activity.
In this review, the germinal center kinase (show MAP4K2 Proteins) III subfamily of mammalian Ste20 (show STK24 Proteins) (sterile 20)-like group of serine/threonine protein kinases comprises Ste20-like (show STK25 Proteins)/oxidant-stress-response kinase 1, MST3 (show STK24 Proteins) mammalian Ste20-like kinase 3 (show STK24 Proteins) and MST4.
crystal of the CCM3 (show PDCD10 Proteins)-MST4 C-terminal domain complex belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = 69.10, b = 69.10, c = 117.57 A
MST4 expression in prostate carcinoma tumor samples & cell lines correlated with tumorigenicity & AR status. Overexpression induced anchorage-independent growth & tumorigenesis.It may have a role in the signal transduction in prostate cancer progression.
Results show that PDCD10 (show PDCD10 Proteins) modulation of ERK (show EPHB2 Proteins) signaling is mediated by MST4, and that PDCD10 (show PDCD10 Proteins) may be a regulatory adaptor necessary for MST4 function, suggesting a link between cerebral cavernous malformation and the ERK-MAPK (show MAPK1 Proteins) cascade via PDCD10 (show PDCD10 Proteins)/MST4.
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
, Mst3 and SOK1-related kinase
, STE20-like kinase MST4
, mammalian STE20-like protein kinase 4
, serine/threonine protein kinase MST4
, serine/threonine-protein kinase MST4
, mammalian Ste20-like protein kinase 4
, mammalian sterile 20-like 4
, serine/threonine-protein kinase MASK