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The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Additionally we are shipping STRAP Antibodies (60) and STRAP Proteins (5) and many more products for this protein.
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MAWD and MAWBP (show PBLD ELISA Kits) were downregulated and associated with the differentiation grade in GC tissues.
STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase.
Strap augments the apoptotic effects of mitochondrial p53 (show TP53 ELISA Kits).
Coexpression of MAWBP (show PBLD ELISA Kits) and MAWD inhibited epithelial mesenchymal transformation, and EMT (show ITK ELISA Kits)-aided malignant cell progression was suppressed in gastric cancer.
Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I (show COL1A2 ELISA Kits)) mRNAs.
both of the TPR and OB-fold domains localize to the chromatin of p53 (show TP53 ELISA Kits) target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 (show TP53 ELISA Kits) response
STRAP protein decreases ubiquitination of intracellular domain of Notch3 (show NOTCH3 ELISA Kits) and may help to stabilize it.
B-MYB (show MYBL2 ELISA Kits) acts as a positive regulator of STRAP
gonucleotide pulldown identified STRAP (serine/threonine kinase receptor-associated protein) as a further protein recruited to the MMP28 (show MMP28 ELISA Kits) promoter and acting functionally with Sp1 (show PSG1 ELISA Kits).
STRAP can act as a negative regulator of ASK1 (show MAP3K5 ELISA Kits).
STRAP Ser (show SIGLEC1 ELISA Kits)(188) phosphorylation in the liver is tightly associated with cell death and proliferation through ASK1 (show MAP3K5 ELISA Kits), TGF-beta (show TGFB1 ELISA Kits), p53 (show TP53 ELISA Kits), and PI3K/PDK1 (show PDPK1 ELISA Kits) pathways, resulting in apoptotic cell death.
both of the TPR (show GRID2 ELISA Kits) and OB-fold domains localize to the chromatin of p53 (show TP53 ELISA Kits) target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 (show TP53 ELISA Kits) response
STRAP regulates c-Jun (show JUN ELISA Kits) stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun (show JUN ELISA Kits).
Gemin8 (show GEMIN8 ELISA Kits) has an essential role in the proper structural organization of the SMN (show STMN1 ELISA Kits) complex and the involvement of the heteromeric subunit containing Gemin6 (show GEMIN6 ELISA Kits), Gemin7 (show GEMIN7 ELISA Kits), Gemin8 (show GEMIN8 ELISA Kits), and Unrip in the recruitment of Sm proteins to the snRNP (show LSM2 ELISA Kits) assembly pathway
NM23-H1 (show NME1 ELISA Kits) and its interacting partner STRAP physically interact with p53 (show TP53 ELISA Kits) and positively regulate its functions, including p53 (show TP53 ELISA Kits)-induced apoptosis and cell cycle arrest
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).
serine-threonine kinase receptor-associated protein
, MAP activator with WD repeats
, WD-40 repeat protein PT-WD
, unr-interacting protein
, UNR-interacting protein