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Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phosp.
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Mouse (Murine) Polyclonal HTR2C Primary Antibody for IEM, ICC - ABIN617931
Holmes: 5-Hydroxytryptamine2C receptors on pudendal motoneurons innervating the external anal sphincter. in Brain research 2005
Show all 4 references for ABIN617931
Human Polyclonal HTR2C Primary Antibody for IF, IHC - ABIN1534244
Xie, Zhu, Zhao, Chang: The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant. in Genomics 1996
Human Polyclonal HTR2C Primary Antibody for ELISA, WB - ABIN185413
Castensson, Aberg, McCarthy, Saetre, Andersson, Jazin: Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005
results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
This study showed that reduced expression of the 5ht1c which modulate antidepressant action in hippocampus.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor (show ESR1 Antibodies) activation in aged male mice.
Results show that mice solely expressing the unedited INI (show PHF5A Antibodies) form of 5-HT2C receptors exhibit a hyperactive HPA (show HPSE Antibodies) axis driven by increased CRH (show CRH Antibodies), a normal response to chronic stress and decreased depressive-like behaviors and fear-associated memory
Chronic intermittent ethanol upregulates 5HT2C receptor signaling in the bed nucleus of the stria terminalis.
findings show that enhanced alcohol drinking behaviour in mice is associated with the degree of 5-HT(2C)R mRNA editing in the nucleus accumbens and dorsal raphe nuceus
Precise temporal control of Gq signals in 5-HT2c-R domains in GABAergic neurons upstream of 5-HT (show DDC Antibodies) neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice.
Results of the current study suggest aggression displayed by TLX (show NR2E1 Antibodies) null and heterozygous mice involves 5-HT(2A (show HTR2A Antibodies)/C) receptors.
Mice lacking Htr2c specifically in POMC (show POMC Antibodies) neurons had normal weight but developed glucoregulatory defects: hyperinsulinemia, hyperglucagonemia, hyperglycemia, & insulin (show INS Antibodies) resistance. These neurons are needed to control energy & glucose homeostasis.
the occurrence of hyperprolactinemia, although asymptomatic, was higher in the presence of the C allele of the rs6318 SNP of the HTR2C gene.
SLC6A14 (show Slc6a14 Antibodies) and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.
RNA element is discovered, which coordinates site-specific RNA editing on HTR2C pre-mRNA by an in vitro editing assay and secondary structural analysis of mutant HTR2C RNA fragments.
No significant differences were found between the genotype distribution and allele frequencies of the OSAHS group and the control group regarding the T102C polymorphisms of the 5-HTR (show F2R Antibodies) 2A gene and the G796C polymorphisms of the 5-HTR (show F2R Antibodies) 2C gene.
Results of the present study do not support a major role of SNPs of HTR2C rs1414334 in the regulation of weight gain or association of serum levels in patients with schizophrenia on clozapine treatment.
ADARB1 (show ADARB1 Antibodies) rs9983925 and rs4819035 and HTR2C rs6318 were associated with suicide attempt risk.
A functional SNP on the HTR2C gene may confer an increased risk for depressive symptoms in White women with a history of significant life stress.
Activation of 5-HT2C receptor promotes neprilysin (show MME Antibodies) expression in glioma cells.
These findings validate our initial observation of association between functional nonsynonymous single nucleotide polymorphism rs6318 on the HTR2C gene and cortisol response to an acute stressor, and extend the results to include females.
found the lack of an association between 5-HT2C Cys (show DNAJC5 Antibodies)/Ser (show SIGLEC1 Antibodies) variants and the risk of bipolar I disorder in Kurds population.
although the expression of the long transcriptional variant of HTR2C is raised in infanticidal animals, the overall patterns of editing in the hypothalamus are similar between the two states.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene.
serotonin receptor 2C
, 5-HT2C receptor
, 5-hydroxytryptamine receptor 1C
, 5-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine receptor-1c
, serotonin 5-HT-2C receptor
, serotonin 1c receptor
, 5-alpha-hydroxytryptamine receptor 2C