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SAA1 encodes a member of the serum amyloid A family of apolipoproteins. Additionally we are shipping SAA1 Antibodies (189) and SAA1 Kits (79) and many more products for this protein.
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Human SAA1 Protein expressed in Escherichia coli (E. coli) - ABIN666889
Betts, Edbrooke, Thakker, Woo: The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. in Scandinavian journal of immunology 1991
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SAA inhibits osteoclast formation from mouse macrophages. SAA blocks RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.
Serum Amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells.
These data demonstrate that SAA stimulates a robust pro-inflammatory response in skeletal muscle myotubes via the TLR2-dependent release of IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins).
Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL (show HSD11B1 Proteins)
SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR (show LDLR Proteins) knockout mice.
Serum amyloid A1alpha induces paracrine IL-8/CXCL8 (show IL8 Proteins) via TLR2 and directly synergizes with this chemokine (show CCL1 Proteins) via CXCR2 (show CXCR2 Proteins) and formyl peptide receptor 2 (show FPR2 Proteins) to recruit neutrophils.
Robust IL-17A (show IL17A Proteins) production was restricted to the ileum, where SFB (show CEBPB Proteins) makes direct contact with the epithelium and induces serum amyloid A proteins 1 and 2 (SAA1/2), which promote local IL-17A (show IL17A Proteins) expression in RORgammat(+) T17 cells.
SAA protein levels increased in both serum and lung within 2-24h after mice were exposed to Aspergillus spores. SAA mRNA levels increased within the first hour after mice were exposed to A. fumigatus.
Saa1 might be a novel inflammatory factor that acts as a chemokine (show CCL1 Proteins) modulator in hepatitis.
Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.
Structure, function and SAA1 gene polymorphisms
Amyloid A overexpressed in renal cell carcinoma (show MOK Proteins) patients and can serve as a prognostic marker.
incorporation of SAA into HDL (show HSD11B1 Proteins) preparations reduced antiinflammatory properties but not to the same extent as HDL (show HSD11B1 Proteins) from AgNO3-injected mice
human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 (show HMGB1 Proteins) release via TLR4 (show TLR4 Proteins) and RAGE (show AGER Proteins) receptors; SAA supplementation worsens the outcome of lethal endotoxemia
The SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis.
Autocrine/paracrine and recombinant human SAA1 via TLR4 (show TLR4 Proteins) stimulate a proinflammatory phenotype that is both part of the early phase of osteogenic differentiation and the development of senescence.
These functional properties set SAA apart from well-characterized inflammatory factors, such as LPS (show IRF6 Proteins) and TNF-alpha (show TNF Proteins), suggesting that it may play a homeostatic role during the course of inflammation.
The detailed analysis of the docking results points to the fact that the best serum amyloid A-Cystatin C (SAA-hCC) binding is achieved by the peptides inclined toward interacting via Lys90 and Arg 96 (with ffhCC Ser98 and Tyr102, respectively).
polymorphisms in the SAA2 gene are associated with milk production traits in Chinese Holstein cows
endometritis gives rise to a systemic acute phase response and an up-regulated endometrial gene expression of SAA and several pro-and anti-inflammatory cytokines
The levels of surfactant protein D and serum amyloid A protein in normal horses and those with bacterial pneumonia are reported.
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
serum amyloid A protein
, serum amyloid A1
, serum amyloid a protein
, serum amyloid A 2
, serum amyloid A-1 protein
, serum amyloid A
, serum amyloid A-3 protein
, tumor protein p53 inducible protein 4
, serum amyloid A2