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SESN1 encodes a member of the sestrin family. Additionally we are shipping Sestrin 1 Kits (9) and Sestrin 1 Proteins (6) and many more products for this protein.
Showing 10 out of 56 products:
Human Polyclonal SESN1 Primary Antibody for EIA, WB - ABIN492723
Budanov, Karin: p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. in Cell 2008
Show all 7 references for ABIN492723
Human Polyclonal SESN1 Primary Antibody for FACS, WB - ABIN391992
Budanov, Sablina, Feinstein, Koonin, Chumakov: Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. in Science (New York, N.Y.) 2004
Show all 3 references for ABIN391992
Human Polyclonal SESN1 Primary Antibody for IHC, ELISA - ABIN1535359
Velasco-Miguel, Buckbinder, Jean, Gelbert, Talbott, Laidlaw, Seizinger, Kley: PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. in Oncogene 1999
Show all 2 references for ABIN1535359
Human Polyclonal SESN1 Primary Antibody for WB - ABIN652375
Ye, Palm, Peng, King, Lindsten, Li, Koumenis, Thompson: GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. in Genes & development 2015
Human Polyclonal SESN1 Primary Antibody for IF, WB - ABIN525920
Renna, Bento, Fleming, Menzies, Siddiqi, Ravikumar, Puri, Garcia-Arencibia, Sadiq, Corrochano, Carter, Brown, Acevedo-Arozena, Rubinsztein: IGF-1 receptor antagonism inhibits autophagy. in Human molecular genetics 2013
identify SESN1 as an indispensable gene for vertebrate left-right asymmetry and a new player in mediating Nodal signaling
Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 (show CRTC2 Antibodies) in appeasing low shear stress induced EC oxidative apoptosis
PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans.
results show that sestrins, a family of proteins whose expression is modulated by p53 (show TP53 Antibodies), are required for regeneration of peroxiredoxins containing Cys (show DNAJC5 Antibodies)-SO(2)H
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Antibodies) or TSC2 (show TSC2 Antibodies). Surprisingly, when coexpressed with a GTP (show AK3 Antibodies)-bound constitutively active form of RagB (show RRAGB Antibodies) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
The enhanced tumor susceptibility of p53 (show TP53 Antibodies)+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for standard 2-year rodent carcinogenicity assays.
Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 (show TP53 Antibodies) and the mTOR (show FRAP1 Antibodies) signaling pathway.
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, nuclear factor XPA26-T2
, p53 activated gene 26
, p53 regulated PA26 nuclear protein
, p53 regulated Pa26 nuclear protein
, p53-regulated protein PA26
, sestrin 1,nuclear factor XPA26-T2