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SESN3 encodes a member of the sestrin family of stress-induced proteins. Additionally we are shipping Sestrin 3 Antibodies (55) and Sestrin 3 Kits (11) and many more products for this protein.
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SESN3 positively regulates the gene network module in macrophages, microglia and neurons.
Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver.
findings suggest the existence of a novel mechanism for the generation of antileukemic responses in CML (show BCR Proteins) cells, involving upregulation of SESN3 expression.
Sestrin 3 is upregulated in T2D and could influence skeletal muscle differentiation without altering glucose and lipid metabolism.
HSF1 (show HSF1 Proteins)/SESN3/reactive oxygen species/p21(Cip1/WAF1 (show CDKN1A Proteins))-mediated deceleration of cell growth may contribute to cell defense systems protecting the organism from excessive proliferation of cells that overexpress activated Ras oncoproteins.
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
Sesn3 liver-specific knockout mice exhibit insulin (show INS Proteins) resistance and glucose intolerance. Sesn3 interacts with and activates mTORC2 (show CRTC2 Proteins) and subsequently stimulates Akt (show AKT1 Proteins) phosphorylation at Ser473.
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Concomitant ablation of Sesn2 (show SESN2 Proteins) and Sesn3 provokes hepatic mTORC1-S6K (show RPS6KB1 Proteins) activation and insulin (show INS Proteins) resistance even in the absence of nutritional overload and obesity.
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
, sestrin 3