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SESN3 encodes a member of the sestrin family of stress-induced proteins. Additionally we are shipping Sestrin 3 Kits (13) and Sestrin 3 Proteins (5) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal SESN3 Primary Antibody for EIA, IHC (p) - ABIN954753
Chen, Jeon, Bhaskar, Nogueira, Sundararajan, Tonic, Park, Hay: FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. in Developmental cell 2010
Show all 2 references for ABIN954753
Human Polyclonal SESN3 Primary Antibody for IHC (p), WB - ABIN656403
Kimball, Ravi, Gordon, Dennis, Jefferson: Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. in The Journal of nutrition 2015
Show all 2 references for ABIN656403
Human Polyclonal SESN3 Primary Antibody for EIA, WB - ABIN492727
Meiller, Alvarez, Drané, Lallemand, Blanchard, Tovey, May: p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated--mice identification of Haeme-oxygenase 1 as a direct p53 target gene. in Nucleic acids research 2007
SESN3 positively regulates the gene network module in macrophages, microglia and neurons.
Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver.
findings suggest the existence of a novel mechanism for the generation of antileukemic responses in CML (show BCR Antibodies) cells, involving upregulation of SESN3 expression.
Sestrin 3 is upregulated in T2D and could influence skeletal muscle differentiation without altering glucose and lipid metabolism.
HSF1 (show HSF1 Antibodies)/SESN3/reactive oxygen species/p21(Cip1/WAF1 (show CDKN1A Antibodies))-mediated deceleration of cell growth may contribute to cell defense systems protecting the organism from excessive proliferation of cells that overexpress activated Ras oncoproteins.
FoxOs inhibit mTORC1 and activate Akt (show AKT1 Antibodies) by inducing the expression of Sestrin3 and Rictor (show RICTOR Antibodies)
Sesn3 liver-specific knockout mice exhibit insulin (show INS Antibodies) resistance and glucose intolerance. Sesn3 interacts with and activates mTORC2 (show CRTC2 Antibodies) and subsequently stimulates Akt (show AKT1 Antibodies) phosphorylation at Ser473.
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Antibodies) or TSC2 (show TSC2 Antibodies). Surprisingly, when coexpressed with a GTP (show AK3 Antibodies)-bound constitutively active form of RagB (show RRAGB Antibodies) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Concomitant ablation of Sesn2 (show SESN2 Antibodies) and Sesn3 provokes hepatic mTORC1-S6K (show RPS6KB1 Antibodies) activation and insulin (show INS Antibodies) resistance even in the absence of nutritional overload and obesity.
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
, sestrin 3