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Sex Comb On Midleg-Like 2 (Drosophila) Proteins (SCML2)

SCML2 encodes a member of the Polycomb group proteins. Additionally we are shipping SCML2 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCML2 10389 Q9UQR0
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Top SCML2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

SCML2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) Interaction Partners

Human Sex Comb On Midleg-Like 2 (Drosophila) (SCML2) interaction partners

  1. SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 (show PRC1 Proteins) localization and also directly enforces repression of certain Polycomb (show CBX2 Proteins) target genes.

  2. SCML2 directly interacts with USP7 (show USP7 Proteins) and drives its localization. SCML2 connects USP7 (show USP7 Proteins) to PRC1.4, allowing for the stabilization of BMI1 (show BMI1 Proteins), and USP7 (show USP7 Proteins) is found on SCML2 and BMI1 (show BMI1 Proteins) target genes.

  3. Because PRC1 (show PRC1 Proteins) complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 (show PRC1 Proteins) complexes to their target genes.

  4. 1.78-A crystal structure of the two MBT (show PRTN3 Proteins) repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT (show PRTN3 Proteins) repeats and these domains.

  5. The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket.

SCML2 Protein Profile

Protein Summary

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.

Gene names and symbols associated with SCML2

  • sex comb on midleg-like 2 (Drosophila) (SCML2)

Protein level used designations for SCML2

sex comb on midleg-like protein 2

GENE ID SPECIES
10389 Homo sapiens
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