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This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. Additionally we are shipping Sex Determining Region Y Antibodies (87) and Sex Determining Region Y Kits (16) and many more products for this protein.
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Human SRY Protein expressed in Wheat germ - ABIN1321373
Holt, Zhang, Binia, Dixon, Vandiedonck, Cookson, Knight, Moffatt: Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). in The Journal of allergy and clinical immunology 2011
The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.
New insights into SRY regulation through identification of 5' conserved sequence are reported.
our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.
Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.
Sry can be replaced by transgenic activation of its downstream target Sox9 (show SOX9 Proteins). This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
SRY binds to various ovarian differentiation genes and represses their activation through WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis
Studies indicate that in most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation.
disprove the hypothesis that the conserved HMG (show SSRP1 Proteins) box domain is the only functional domain of Sry, and highlight an evolutionary paradox whereby mouse Sry has evolved a novel bifunctional module to activate Sox9 (show SOX9 Proteins) directly
this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty.
70-kDa heat shock cognate protein hsc70 (show HSPA8 Proteins) mediates calmodulin-dependent nuclear import of the sex-determining factor SRY.
a single-nucleotide polymorphism in the amelogenin (show AMELX Proteins) gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported.
Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis.
Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9 (show SOX9 Proteins), demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
SRY is involved in the maintenance of cancer stem-like characteristics through OCT4 (show POU5F1 Proteins).
The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender
These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male
Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET (show RET Proteins) gene by competing with SOX10 (show SOX10 Proteins) for its interaction with PAX3 (show PAX3 Proteins) and NKX2-1 (show NKX2-1 Proteins) repressing their transcriptional expression and RET's as well.
High levels of SRY expression correlated with cancer progression and poor HCC (show FAM126A Proteins) patient survival. However, high SRY levels are not significantly correlated with HCC (show FAM126A Proteins) sex bias.
Findings demonstrate that the folding, trafficking, and gene-regulatory function of testis-determining factor SRY requires an invariant aromatic "buttress" beneath its specific DNA-bending surface.
analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus
This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome)\; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
sex determining region Y
, sex-determining region Y protein
, testis determining-Y
, testis-determining factor
, essential protein for sex determination in human males
, sex-determining region on Y
, testis-determining factor on Y
, HMG box transcription factor Sry1
, HMG box transcription factor Sry3BI
, Testis determining locus
, sex determining region of Chr Y
, sex determining region on Y
, sex determining factor Y
, sex-determining region of the Y-chromosome
, sex determining region Y protein
, sex-determining protein