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Shugoshin-Like 1 (S. Pombe) (SGOL1) ELISA Kits

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Additionally we are shipping SGOL1 Antibodies (50) and SGOL1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SGOL1 SGOL1 363174  
SGOL1 151648 Q5FBB7
Anti-Mouse SGOL1 SGOL1 72415 Q9CXH7
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More ELISA Kits for SGOL1 Interaction Partners

Human Shugoshin-Like 1 (S. Pombe) (SGOL1) interaction partners

  1. Cohesin complex is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A recruitment.

  2. Sgo1 co-recruits Aurora B and PP2A to centromeres of unattached chromosomes.

  3. Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)).

  4. our findings strongly suggest that CIP2A (show KIAA1524 ELISA Kits) promotes cell cycle progression, premature chromosome segregation, and aneuploidy, possibly through a novel interaction with Sgol1.

  5. Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription.

  6. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut (show GUSB ELISA Kits) rhythm.

  7. Bub1 (show BUB1 ELISA Kits)-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation.

  8. The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3.

  9. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.

  10. SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance

Mouse (Murine) Shugoshin-Like 1 (S. Pombe) (SGOL1) interaction partners

  1. Data show that compound mutant spindle assembly checkpoint components BubR1 (show BUB1B ELISA Kits) and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  2. Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development.

  3. Sgo1(-/+)-mediated ME-CIN (show PDXP ELISA Kits) strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself.

  4. Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells.

  5. It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1 (show BUB1 ELISA Kits)-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  6. Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1.

  7. report structure and function of the PP2A-shugoshin interaction.

SGOL1 Antigen Profile

Antigen Summary

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.

Gene names and symbols associated with SGOL1

  • shugoshin-like 1 (S. pombe) (Sgol1) antibody
  • shugoshin centromeric cohesion1 (sgo1) antibody
  • shugoshin-like 1 (sgol1) antibody
  • shugoshin-like 1 (S. pombe) (SGOL1) antibody
  • 3300001M08Rik antibody
  • C81037 antibody
  • NY-BR-85 antibody
  • SGO antibody
  • Sgo1 antibody

Protein level used designations for SGOL1

AY109536_SNP , CL5684_1 , CL5684_1_ov , gnp_AW055587 , gpm134 , p-std614083G09 , shugoshin-1 , shugoshin-like protein , shugosin centromeric cohesion1 , std614083G09 , zmSGO1 , xsgo , hSgo1 , serologically defined breast cancer antigen NY-BR-85 , shugoshin 1AB protein , shugoshin 1CD protein , shugoshin 1EF protein , shugoshin 1GH protein , shugoshin 1KL protein , shugoshin-like 1 , shugoshin 1A protein

363174 Rattus norvegicus
606461 Zea mays
735145 Xenopus laevis
151648 Homo sapiens
72415 Mus musculus
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