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anti-Shwachman-Bodian-Diamond Syndrome (SBDS) Antibodies

SBDS encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. Additionally we are shipping Shwachman-Bodian-Diamond Syndrome Proteins (17) and Shwachman-Bodian-Diamond Syndrome Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SBDS 51119 Q9Y3A5
SBDS 288615 Q5RK30
SBDS 66711 P70122
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Top anti-Shwachman-Bodian-Diamond Syndrome Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SBDS Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SBDS Antibody Titration: 1.25ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC, WB SBDS antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X SBDS antibody used at 1.25 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Rabbit Un-conjugated IHC, WB SBDS antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X SBDS antibody used at 2.5 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details

SBDS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human
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Rat (Rattus)


Mouse (Murine)


Top referenced anti-Shwachman-Bodian-Diamond Syndrome Antibodies

  1. Human Monoclonal SBDS Primary Antibody for EIA, WB - ABIN1449399 : Boocock, Morrison, Popovic, Richards, Ellis, Durie, Rommens: Mutations in SBDS are associated with Shwachman-Diamond syndrome. in Nature genetics 2003 (PubMed)
    Show all 3 references for ABIN1449399

  2. Chicken Polyclonal SBDS Primary Antibody for IHC, WB - ABIN2782336 : Austin, Leary, Shimamura: The Shwachman-Diamond SBDS protein localizes to the nucleolus. in Blood 2005 (PubMed)
    Show all 2 references for ABIN2782336

More Antibodies against Shwachman-Bodian-Diamond Syndrome Interaction Partners

Zebrafish Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. Knockdown of the zebrafish sbds ortholog fully recapitulates the spectrum of developmental abnormalities observed in the human Shwachman-Bodian-Diamond syndrome.

  2. The sbds gene function is essential for normal pancreas and myeloid development in zebrafish. Zebrafish is a model system to study sbds gene function and for evaluation of novel therapies for Shwachman-Diamond syndrome.

Human Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. Upon EFL1 (show EFNA1 Antibodies) binding, SBDS is repositioned around helix 69, thus facilitating a conformational switch in EFL1 (show EFNA1 Antibodies) that displaces eIF6 (show EIF6 Antibodies) by competing for an overlapping binding site on the 60S ribosomal subunit.

  2. Association of EFL1 (show EFNA1 Antibodies) to SBDS did not modify the affinity for GTP (show AK3 Antibodies) but dramatically decreased that for GDP by increasing the dissociation rate of the nucleotide.

  3. Genetic variations in exon 2 of SBDS gene do not appear to be contributing to aplastic anemia in the north Indian population.

  4. The interaction between EFL1 (show EFNA1 Antibodies) and SBDS was analyzed by size exclusion chromatography, gel shift assay, and isothermal titration calorimetry. The results showed that EFL1 (show EFNA1 Antibodies) interacted directly with SBDS.

  5. SBDS protein acts as a nucleotide exchange factor that stabilizes binding to GTP (show AK3 Antibodies) for human GTPase (show RACGAP1 Antibodies).

  6. Lack of mutation in exon 2 of sbds protein in acute myeloid leukemia (show BCL11A Antibodies) suggests this subset is unlikely to have underlying sds (show SDS Antibodies)

  7. We conclude that knockdown of SBDS leads to growth inhibition and defects in ribosome maturation

  8. SBDS protein facilitates the release of eIF6 (show EIF6 Antibodies), a factor that prevents ribosome joining.

  9. mesenchymal stromal cells from MDS (show PAFAH1B1 Antibodies) patients show low gene and protein expression of DICER1 (show DICER1 Antibodies) and DROSHA (show DROSHA Antibodies) which are involved in the microRNA biogenesis, as well as their target gene SBDS.

  10. Erythropoiesis (in normal stem cells or in cells from Shwachman-Diamond syndrome patients) requires SBDS. Knockdown of SBDS leads to oxidative stress, to increased levels of ROS (show ROS1 Antibodies) during erythroid differentiation, and disrupts ribosome biogenesis.

Mouse (Murine) Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

  2. Sbds genotypes correlated with phenotypes in a mouse model of Shwachman-Diamond syndrome. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes.

  3. Sbds is required for osteoclastogenesis by regulating monocyte migration via Rac2 (show RAC2 Antibodies) and osteoclast differentiation signaling downstream of RANK.

  4. Sbds is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation.

  5. loss of Sbds is sufficient to induce abnormalities in hematopoiesis

  6. The majority of Shwachman-Diamond syndrome cases are results of mutations in SBDS gene on chromosone 7q11.

Shwachman-Bodian-Diamond Syndrome (SBDS) Antigen Profile

Protein Summary

This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.

Gene names and symbols associated with SBDS

  • Shwachman-Bodian-Diamond syndrome (sbds) antibody
  • shwachman-Bodian-Diamond syndrome (LOAG_04440) antibody
  • Shwachman-Bodian-Diamond syndrome (SBDS) antibody
  • Shwachman-Bodian-Diamond syndrome (Sbds) antibody
  • Shwachman-Bodian-Diamond syndrome homolog (human) (Sbds) antibody
  • 4733401P19Rik antibody
  • AI836084 antibody
  • CGI-97 antibody
  • SDS antibody
  • SWDS antibody
  • zgc:56700 antibody

Protein level used designations for SBDS

ribosome maturation protein SBDS , shwachman-Bodian-Diamond syndrome protein homolog , shwachman-Bodian-Diamond syndrome , Shwachman-Bodian-Diamond syndrome homolog , protein 22A3

GENE ID SPECIES
448365 Xenopus (Silurana) tropicalis
9941848 Loa loa
394096 Danio rerio
100049749 Xenopus laevis
417477 Gallus gallus
51119 Homo sapiens
607017 Canis lupus familiaris
513237 Bos taurus
288615 Rattus norvegicus
100172536 Pongo abelii
66711 Mus musculus
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