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SBDS encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. Additionally we are shipping Shwachman-Bodian-Diamond Syndrome Proteins (17) and Shwachman-Bodian-Diamond Syndrome Kits (5) and many more products for this protein.
Showing 10 out of 44 products:
Human Monoclonal SBDS Primary Antibody for EIA, WB - ABIN1449399
Boocock, Morrison, Popovic, Richards, Ellis, Durie, Rommens: Mutations in SBDS are associated with Shwachman-Diamond syndrome. in Nature genetics 2003
Show all 3 references for ABIN1449399
Chicken Polyclonal SBDS Primary Antibody for IHC, WB - ABIN2782336
Austin, Leary, Shimamura: The Shwachman-Diamond SBDS protein localizes to the nucleolus. in Blood 2005
Show all 2 references for ABIN2782336
Knockdown of the zebrafish sbds ortholog fully recapitulates the spectrum of developmental abnormalities observed in the human Shwachman-Bodian-Diamond syndrome.
The sbds gene function is essential for normal pancreas and myeloid development in zebrafish. Zebrafish is a model system to study sbds gene function and for evaluation of novel therapies for Shwachman-Diamond syndrome.
The clinical diagnosis was confirmed by detection of compound heterozygous mutations in SBDS using whole-exome sequencing: a recurrent intronic mutation causing aberrant splicing (c.258+2T>C) and a novel missense variant in a highly conserved codon (c.41A>G, p.Asn14Ser), considered to be damaging for the protein structure by in silico prediction programs
Upon EFL1 (show EFNA1 Antibodies) binding, SBDS is repositioned around helix 69, thus facilitating a conformational switch in EFL1 (show EFNA1 Antibodies) that displaces eIF6 (show EIF6 Antibodies) by competing for an overlapping binding site on the 60S ribosomal subunit.
Association of EFL1 (show EFNA1 Antibodies) to SBDS did not modify the affinity for GTP (show AK3 Antibodies) but dramatically decreased that for GDP by increasing the dissociation rate of the nucleotide.
Genetic variations in exon 2 of SBDS gene do not appear to be contributing to aplastic anemia in the north Indian population.
The interaction between EFL1 (show EFNA1 Antibodies) and SBDS was analyzed by size exclusion chromatography, gel shift assay, and isothermal titration calorimetry. The results showed that EFL1 (show EFNA1 Antibodies) interacted directly with SBDS.
SBDS protein acts as a nucleotide exchange factor that stabilizes binding to GTP (show AK3 Antibodies) for human GTPase (show RACGAP1 Antibodies).
Lack of mutation in exon 2 of sbds protein in acute myeloid leukemia (show BCL11A Antibodies) suggests this subset is unlikely to have underlying sds (show SDS Antibodies)
We conclude that knockdown of SBDS leads to growth inhibition and defects in ribosome maturation
SBDS protein facilitates the release of eIF6 (show EIF6 Antibodies), a factor that prevents ribosome joining.
mesenchymal stromal cells from MDS (show PAFAH1B1 Antibodies) patients show low gene and protein expression of DICER1 (show DICER1 Antibodies) and DROSHA (show DROSHA Antibodies) which are involved in the microRNA biogenesis, as well as their target gene SBDS.
Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes
Sbds genotypes correlated with phenotypes in a mouse model of Shwachman-Diamond syndrome. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes.
Sbds is required for osteoclastogenesis by regulating monocyte migration via Rac2 (show RAC2 Antibodies) and osteoclast differentiation signaling downstream of RANK.
Sbds is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation.
loss of Sbds is sufficient to induce abnormalities in hematopoiesis
The majority of Shwachman-Diamond syndrome cases are results of mutations in SBDS gene on chromosone 7q11.
This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
ribosome maturation protein SBDS
, shwachman-Bodian-Diamond syndrome protein homolog
, shwachman-Bodian-Diamond syndrome
, Shwachman-Bodian-Diamond syndrome homolog
, protein 22A3