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SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH2 Antibodies (54) and SIAH2 Kits (3) and many more products for this protein.
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Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (show HIF1A Proteins) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.
Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.
A catalysis-independent role for AKR1C3 (show AKR1C3 Proteins) on AR activity via Siah2 has been identified.
Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.
Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions
our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (show TP53BP2 Proteins) stability.
Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival
modulation of PPARgamma (show PPARG Proteins) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (show PPARG Proteins) activation in adipocytes
Siah2 is a key regulator of hypoxia-induced mitochondrial fission and plays role in ischemic injury
Siah2-dependent concerted activity of HIF and FoxA2 (show FOXA2 Proteins) regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
The E3 ubiquitin ligase (show MUL1 Proteins) activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.
SIAH2 is associated with a tumor promoting role in breast cancer.
Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma
Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia
The expression of SIAH2 is increased in human lung cancer.
the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of the Hippo pathway, in response to hypoxia.
The down-regulation of SIAH2 conferred sensitivity to anti-cancer drugs. The results of the study indicated that the miR (show MLXIP Proteins)-335/SIAH2/HDAC3 (show HDAC3 Proteins) axis regulates the response to anti-cancer drugs.
Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Proteins) RevErbalpha (Nr1d1 (show NR1D1 Proteins)) and lengthens period length.
Data indicate that ubiquitin ligase Siah (show SIAH1 Proteins) as a regulator of to Mesenchymal Transition (EMT (show ITK Proteins)) by controlling the abundance of the key transcription factor Zeb1, while Siah (show SIAH1 Proteins) itself is subject to regulation by EMT (show ITK Proteins)-inducing factors.
molecular basis of Siah1 (show SIAH1 Proteins) and Siah2 E3 ubiquitin ligase (show MUL1 Proteins) substrate specificity
Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.
seven in absentia homolog 2
, seven in absentia-like protein
, E3 ubiquitin-protein ligase SIAH2
, E3 ubiquitin-protein ligase Siah2
, seven in absentia 2-like
, seven in absentia homolog 2-like
, ubiquitin ligase siah2
, seven in absentia 2
, E3 ubiquitin-protein ligase siah2