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anti-Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Antibodies

SIGLEC1 encodes a member of the immunoglobulin superfamily. Additionally we are shipping Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Kits (21) and Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC1 20612 Q62230
SIGLEC1 6614 Q9BZZ2
SIGLEC1 311426  
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Top anti-Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Antibodies at antibodies-online.com

Showing 10 out of 168 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rat FITC FACS 0.1 mg Log in to see 6 to 8 Days
$797.50
Details
Mouse Rat Un-conjugated FACS, IHC (fro), IF 0.1 mg Log in to see 6 to 8 Days
$346.50
Details
Mouse Rat Biotin IHC (fro)   0.2 mg Log in to see 6 to 8 Days
$566.50
Details
Mouse Rat Un-conjugated FACS, IHC (fro)   0.2 mg Log in to see 6 to 8 Days
$511.50
Details
Mouse Rat FITC FACS, IF   0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Human Mouse FITC FACS   0.1 mg Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$367.00
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$367.00
Details
Pig Mouse FITC FACS   0.1 mg Log in to see 6 to 8 Days
$753.50
Details
Mouse Rat PerCP-Cy5.5 FACS 100 μg Log in to see 10 to 12 Days
$353.29
Details

SIGLEC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Antibodies

  1. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS, IF - ABIN118291 : Kraal, Janse: Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody. in Immunology 1986 (PubMed)
    Show all 12 references for ABIN118291

  2. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS, IP - ABIN2657137 : Crocker, Gordon: Isolation and characterization of resident stromal macrophages and hematopoietic cell clusters from mouse bone marrow. in The Journal of experimental medicine 1985 (PubMed)
    Show all 11 references for ABIN2657137

  3. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS, IHC (fro) - ABIN317446 : Crocker, Kelm, Dubois, Martin, McWilliam, Shotton, Paulson, Gordon: Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. in The EMBO journal 1991 (PubMed)
    Show all 10 references for ABIN317446

  4. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN317444 : Kaisho, Takeda, Tsujimura, Kawai, Nomura, Terada, Akira: IkappaB kinase alpha is essential for mature B cell development and function. in The Journal of experimental medicine 2001 (PubMed)
    Show all 10 references for ABIN317444

  5. Pig (Porcine) Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN317425 : Bullido, Gómez del Moral, Alonso, Ezquerra, Zapata, Sánchez, Ortuño, Alvarez, Domínguez: Monoclonal antibodies specific for porcine monocytes/macrophages: macrophage heterogeneity in the pig evidenced by the expression of surface antigens. in Tissue antigens 1997 (PubMed)
    Show all 3 references for ABIN317425

  6. Human Monoclonal SIGLEC1 Primary Antibody for FACS - ABIN316948 : Kirchberger, Majdic, Steinberger, Blüml, Pfistershammer, Zlabinger, Deszcz, Kuechler, Knapp, Stöckl: Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 2 references for ABIN316948

  7. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody for IHC (fro) - ABIN118290 : Movita, Kreefft, Biesta, van Oudenaren, Leenen, Janssen, Boonstra: Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages. in Journal of leukocyte biology 2012 (PubMed)
    Show all 2 references for ABIN118290

More Antibodies against Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Interaction Partners

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. Viral infection significantly upregulated Siglec1 expression in mouse macrophages in an IFN/JAK (show JAK3 Antibodies)/STAT1 (show STAT1 Antibodies) pathway-dependent manner.

  2. Siglec-1 is a key receptor for macrophage/lymphocyte trans-infection of surface-bound virions, and the N-acyl side chain of sialic acid is a critical determinant for the Siglec-1/MLV interaction.

  3. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread.

  4. CD169(+) monocytes and macrophages have a critical role in preventing excessive inflammation in renal ischemia-reperfusion injury by downregulating intercellular adhesion molecule-1 (show ICAM1 Antibodies) expression on vascular endothelial cells.

  5. results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses

  6. Sialoadhesin is critical for macrophages to phagocytose and clear the sialylated pathogen group B Streptococcus.

  7. prion (show PRNP Antibodies) pathogenesis was unaltered in sialoadhesin-deficient mice

  8. CD169(-/-) mice demonstrated an enhanced response to antigen-pulsed exosomes. This is the first report of a role for CD169 in the capture of exosomes and its potential to mediate the immune response to exosomal antigen.

  9. Siglec-1 can interact with SR-BI (show SCARB1 Antibodies) in the phagocytosis of oxLDL by macrophages, rather than act as an independent receptor for oxLDL.

  10. the CD169/Sn endocytic pathway is conserved and capable of presenting lipid antigens to iNKT cells

Human Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. Siglec-1 on myeloid cells could fuel novel CD4 (show CD4 Antibodies)(+) T-cell infections and contribute to HIV-1 dissemination in vivo.

  2. evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells

  3. Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses

  4. GM3 (show GRM6 Antibodies)-CD169 binding is a gp120 (show ITIH4 Antibodies)-independent signal for sequestration and preservation of HIV-1 infectivity.

  5. The most abundant cytokine present in semen (TGF-beta1 (show TGFB1 Antibodies)) is able to enhance specifically the expression of an important molecule (CD169) involved in the capture and transmission of HIV-1 particles from the mucosal lumen to the submucosal compartment.

  6. Siglec-1 may play a proinflammatory role in stimulating lymphocyte proliferation and activation in rheumatoid arthritis.

  7. CD169(+) macrophages in RLNs promote CD8 (show CD8A Antibodies)(+) T-cell-mediated antitumor immunity.

  8. downregulation of CD169 expression or neutralizing CD169 function abrogated dendritic cell-mediated HIV-1 capture and trans infection, while exogenous expression of CD169 in receptor-naive cells rescued glycosphingolipid-dependent capture and trans infection.

  9. Based on increased SIGLEC1 expression in circulating monocytes, findings suggest a role for SIGLEC1 in the chronic progressive phases of multiple sclerosis.

  10. the CD169/Sn endocytic pathway is conserved and capable of presenting lipid antigens to iNKT cells

Pig (Porcine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end.

  2. Fusion protein of sialoadhesin and domains 5-9 of CD163 (show CD163 Antibodies) receptors blocked the respiratory syndrome virus infection.

  3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin.

  4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology.

  5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently.

  6. ). These results provided fundamental evidence for CD163 (show CD163 Antibodies) and SN as two functional candidate genes affecting immunity in pigs.

  7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production

  8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.

  9. Sialoadhesin is confirmed as a PRRSV (porcine reproductive and respiratory syndrome virus)internalization receptor and is shown to interact with CD163 (show CD163 Antibodies) in PRRSV entry.

  10. Clear changes in the quantity of sialoadhesin(+) and CD163 (show CD163 Antibodies)(+) macrophages in the placentas and organs of embryos/fetuses during gestation.

Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Antigen Profile

Protein Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound\; however, the full-length nature of this variant has not been determined.

Gene names and symbols associated with SIGLEC1

  • sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1) antibody
  • sialoadhesin (LOC100345836) antibody
  • sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1) antibody
  • sialoadhesin (SIGLEC-1) antibody
  • CD169 antibody
  • dJ1009E24.1 antibody
  • p210 antibody
  • pSn antibody
  • SA antibody
  • SIGLEC-1 antibody
  • SIGLEC1 antibody
  • SN antibody

Protein level used designations for SIGLEC1

sialoadhesin , SER , sheep erythrocyte receptor , sialic acid-binding Ig-like lectin 1 , sialic acid-binding immunoglobulin-like lectin 1 , Sialic acid-binding Ig-like lectin 1

GENE ID SPECIES
469866 Pan troglodytes
100345836 Oryctolagus cuniculus
20612 Mus musculus
6614 Homo sapiens
311426 Rattus norvegicus
539759 Bos taurus
397623 Sus scrofa
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