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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Kits (12) and SIGLEC10 Proteins (7) and many more products for this protein.
Showing 10 out of 79 products:
Human Monoclonal SIGLEC10 Primary Antibody for IF, WB - ABIN2663881
Kitzig, Martinez-Barriocanal, López-Botet, Sayós: Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. in Biochemical and biophysical research communications 2002
Show all 6 references for ABIN2663881
Human Monoclonal SIGLEC10 Primary Antibody for FACS, IF - ABIN2658387
Chen, Tang, Zheng, Liu: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. in Science (New York, N.Y.) 2009
Show all 6 references for ABIN2658387
Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476478
Spiegelman, Israel, Bouchard, Willett: Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? in The American journal of clinical nutrition 1992
Show all 4 references for ABIN2476478
Human Polyclonal SIGLEC10 Primary Antibody for WB - ABIN2784077
Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. in Genome biology 2008
Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
Siglec-10-VAP-1 (show AOC3 Antibodies) interaction seems to mediate lymphocyte adhesion to endothelium
Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.
Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Antibodies) and the proapoptotic factor BIM (show BCL2L11 Antibodies) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
Siglec-G-CD24 (show CD24 Antibodies) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.
Siglec-G sialic acid-dependent binding to the BCR (show BCR Antibodies) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 Antibodies)) on B cells.
Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS Antibodies) mice.
Siglec-G inhibits B cell activation (show BLNK Antibodies) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA Antibodies) in various B cell compartments.
Data reveal a negative feedback loop of RIG-I (show DDX58 Antibodies) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.
The critical importance of pre-BCR (show BCR Antibodies) and BCR (show BCR Antibodies) receptor levels for the normal development of B-lymphocyte (show AKAP17A Antibodies) subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.
Siglec-G-deficient B1a lymphocytes survive longer in vitro and become the dominant population when injected in competition with wild-type B1a cells into Rag1 (show RAG1 Antibodies)-deficient mice.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
sialic acid binding Ig-like lectin 10
, sialic acid-binding Ig-like lectin 10-like
, sialic acid binding Ig-like lectin G
, sialic acid-binding Ig-like lectin 10
, sialic acid binding Ig-like lectin 10 Ig-like lectin 7
, siglec-like gene 2
, siglec-like protein 2