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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Antibodies (82) and SIGLEC10 Proteins (7) and many more products for this protein.
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Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)).
Siglec-10-VAP-1 (show AOC3 ELISA Kits) interaction seems to mediate lymphocyte adhesion to endothelium
Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.
Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN ELISA Kits) and the proapoptotic factor BIM (show BCL2L11 ELISA Kits) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
Siglec-G-CD24 (show CD24 ELISA Kits) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.
Siglec-G sialic acid-dependent binding to the BCR (show BCR ELISA Kits) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 ELISA Kits)) on B cells.
Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS ELISA Kits) mice.
Siglec-G inhibits B cell activation (show BLNK ELISA Kits) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA ELISA Kits) in various B cell compartments.
Data reveal a negative feedback loop of RIG-I (show DDX58 ELISA Kits) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.
The critical importance of pre-BCR (show BCR ELISA Kits) and BCR (show BCR ELISA Kits) receptor levels for the normal development of B-lymphocyte (show AKAP17A ELISA Kits) subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.
Siglec-G-deficient B1a lymphocytes survive longer in vitro and become the dominant population when injected in competition with wild-type B1a cells into Rag1 (show RAG1 ELISA Kits)-deficient mice.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
sialic acid binding Ig-like lectin 10
, sialic acid-binding Ig-like lectin 10-like
, sialic acid binding Ig-like lectin G
, sialic acid-binding Ig-like lectin 10
, sialic acid binding Ig-like lectin 10 Ig-like lectin 7
, siglec-like gene 2
, siglec-like protein 2