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anti-Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) Antibodies

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. Additionally we are shipping SIGLEC12 Kits (27) and SIGLEC12 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC12 89858 Q96PQ1
SIGLEC12 83382 Q91Y57
SIGLEC12    
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Top anti-SIGLEC12 Antibodies at antibodies-online.com

Showing 10 out of 50 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of SIGLEC12 Antibody (C-term) (ABIN650651) in mouse bladder tissue lysates (35 µg/lane). SIGLEC12 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human spleen tissue reacted with DLX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SIGLEC12 Antibody (C-term) in mouse bladder tissue lysates (35ug/lane). SIGLEC12 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$365.20
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$365.20
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$376.20
Details

SIGLEC12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Top referenced anti-SIGLEC12 Antibodies

  1. Human Polyclonal SIGLEC12 Primary Antibody for IHC (p), WB - ABIN650651 : Angata, Varki, Varki: A second uniquely human mutation affecting sialic acid biology. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN650651

  2. Human Polyclonal SIGLEC12 Primary Antibody for EIA, WB - ABIN453827 : Yu, Lai, Maoui, Banville, Shen: Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN453827

More Antibodies against SIGLEC12 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) interaction partners

  1. cardiovascular outcomes may differ based on SIGLEC12 genotype, and antihypertensive treatment strategy.

  2. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) interaction partners

  1. indicate that Siglec-9 (show SIGLEC9 Antibodies) affects several different signaling pathways in IL-4 (show IL4 Antibodies)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Antibodies) in Siglec-9 (show SIGLEC9 Antibodies)-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Antibodies) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Antibodies)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) interaction and endotoxemia.

  4. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Antibodies)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  5. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Antibodies) activation and ROS (show ROS1 Antibodies) production

  6. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Antibodies)-expressing tumor in the transgenic mice.

  7. Siglec-9 (show SIGLEC9 Antibodies) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Antibodies) and that this signaling may be another MUC1 (show MUC1 Antibodies)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. Siglec-E is induced in a MyD88 (show MYD88 Antibodies)-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB (show NFKB1 Antibodies) antiviral responses by directly inhibiting TLR-induced antiviral cytokine production.

SIGLEC12 Antigen Profile

Protein Summary

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

Gene names and symbols associated with SIGLEC12

  • sialic acid binding Ig-like lectin 12 (SIGLEC12) antibody
  • sialic acid binding Ig-like lectin 12 (gene/pseudogene) (SIGLEC12) antibody
  • sialic acid binding Ig-like lectin 12-like (LOC618463) antibody
  • sialic acid binding Ig-like lectin E (Siglece) antibody
  • Cd170 antibody
  • mSiglec-E antibody
  • S2V antibody
  • Siglec-XII antibody
  • Siglec5 antibody
  • Siglec9 antibody
  • Siglec12 antibody
  • Siglecl1 antibody
  • SLG antibody

Protein level used designations for SIGLEC12

SIGLEC-like 1 , sialic acid binding immunoglobulin-like lectin-like protein 1 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding lectin Siglec-L1 , siglec-12 , siglec-L1 , sialic acid binding Ig-like lectin 12 , MIS , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding immunoglobulin-like lectin E , siglec-5 , siglec-E

GENE ID SPECIES
484344 Canis lupus familiaris
450120 Pan troglodytes
89858 Homo sapiens
618463 Bos taurus
83382 Mus musculus
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