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Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) Proteins (SIGLEC12)

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. Additionally we are shipping SIGLEC12 Antibodies (50) and SIGLEC12 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC12 89858 Q96PQ1
SIGLEC12 83382 Q91Y57
SIGLEC12    
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Top SIGLEC12 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$855.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,303.67
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$794.65
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

SIGLEC12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Pan troglodytes

More Proteins for Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) interaction partners

  1. cardiovascular outcomes may differ based on SIGLEC12 genotype, and antihypertensive treatment strategy.

  2. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) interaction partners

  1. indicate that Siglec-9 (show SIGLEC9 Proteins) affects several different signaling pathways in IL-4 (show IL4 Proteins)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Proteins) in Siglec-9 (show SIGLEC9 Proteins)-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Proteins) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Proteins)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Proteins)) interaction and endotoxemia.

  4. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Proteins)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  5. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Proteins) activation and ROS (show ROS1 Proteins) production

  6. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Proteins)-expressing tumor in the transgenic mice.

  7. Siglec-9 (show SIGLEC9 Proteins) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Proteins) and that this signaling may be another MUC1 (show MUC1 Proteins)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. Siglec-E is induced in a MyD88 (show MYD88 Proteins)-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB (show NFKB1 Proteins) antiviral responses by directly inhibiting TLR-induced antiviral cytokine production.

SIGLEC12 Protein Profile

Protein Summary

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

Gene names and symbols associated with SIGLEC12

  • sialic acid binding Ig-like lectin 12 (SIGLEC12)
  • sialic acid binding Ig-like lectin 12 (gene/pseudogene) (SIGLEC12)
  • sialic acid binding Ig-like lectin 12-like (LOC618463)
  • sialic acid binding Ig-like lectin E (Siglece)
  • Cd170 protein
  • mSiglec-E protein
  • S2V protein
  • Siglec-XII protein
  • Siglec5 protein
  • Siglec9 protein
  • Siglec12 protein
  • Siglecl1 protein
  • SLG protein

Protein level used designations for SIGLEC12

SIGLEC-like 1 , sialic acid binding immunoglobulin-like lectin-like protein 1 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding lectin Siglec-L1 , siglec-12 , siglec-L1 , sialic acid binding Ig-like lectin 12 , MIS , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding immunoglobulin-like lectin E , siglec-5 , siglec-E

GENE ID SPECIES
484344 Canis lupus familiaris
450120 Pan troglodytes
89858 Homo sapiens
618463 Bos taurus
83382 Mus musculus
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