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anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Antibodies

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Proteins (19) and SIGLEC5 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC5 8778 O15389
SIGLEC5 233186 Q920G3
SIGLEC5 292843  
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Top anti-SIGLEC5 Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CD170 / SIGLEC5 Antibody  in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$282.64
Details
Human Mouse APC ELISA 100 Tests Log in to see 10 to 12 Days
$320.68
Details
Human Rabbit Un-conjugated WB SIGLEC5 Antibody (N-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICFC 100 μg Log in to see 10 to 12 Days
$211.97
Details
Human Rabbit Un-conjugated WB The anti-Siglec5 C-term Pab (ABIN388415) is used in Western blot to detect Siglec5 in mouse liver tissue lysate. SIGLEC5 Antibody (ABIN388415) western blot analysis in SK-BR-3 cell line lysates (35 µg/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Siglec5 N-term Pab (ABIN388414) is used in Western blot to detect Siglec5 in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated FACS, IHC (p), WB 100 μg Log in to see 8 to 10 Days
$595.83
Details

SIGLEC5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Mouse (Murine) , ,
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Rat (Rattus) ,


Top referenced anti-SIGLEC5 Antibodies

  1. Human Monoclonal SIGLEC5 Primary Antibody for ICFC - ABIN2664288 : Zhuravleva, Trandem, Sun: Structural implications of Siglec-5-mediated sialoglycan recognition. in Journal of molecular biology 2007 (PubMed)
    Show all 7 references for ABIN2664288

  2. Human Monoclonal SIGLEC5 Primary Antibody for FACS - ABIN2662475 : Soto, Stein, Hurtado-Ziola, Hedrick, Varki: Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for ABIN2662475

  3. Human Monoclonal SIGLEC5 Primary Antibody for ELISA - ABIN2656969 : Carlin, Chang, Areschoug, Lindahl, Hurtado-Ziola, King, Varki, Nizet: Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. in The Journal of experimental medicine 2009 (PubMed)
    Show all 7 references for ABIN2656969

  4. Human Polyclonal SIGLEC5 Primary Antibody for EIA, WB - ABIN951208 : Gunnarsson, Levander, Påhlsson, Grenegård: The acute-phase protein alpha 1-acid glycoprotein (AGP) induces rises in cytosolic Ca2+ in neutrophil granulocytes via sialic acid binding immunoglobulin-like lectins (siglecs). in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 (PubMed)
    Show all 5 references for ABIN951208

  5. Human Polyclonal SIGLEC5 Primary Antibody for EIA, WB - ABIN357144 : Erickson-Miller, Freeman, Hopson, DAlessio, Fischer, Kikly, Abrahamson, Holmes, King: Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. in Experimental hematology 2003 (PubMed)
    Show all 3 references for ABIN357144

  6. Human Polyclonal SIGLEC5 Primary Antibody for EIA, IHC (p) - ABIN357143 : Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN357143

More Antibodies against SIGLEC5 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. An unbiased screen revealed Hsp70 (show HSP70 Antibodies) as a ligand for Siglec-5 and Siglec-14 (show SIGLEC14 Antibodies). Hsp70 (show HSP70 Antibodies) stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 (show SIGLEC14 Antibodies) is pro-inflammatory.

  2. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  3. we found that secretory IgA is taken up by M cells via the Dectin-1 (show CLEC7A Antibodies) receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  4. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  5. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  6. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  7. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  8. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  9. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  10. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated (show SULF1 Antibodies) oligosaccharides containing sialic acid.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. indicate that Siglec-9 (show SIGLEC9 Antibodies) affects several different signaling pathways in IL-4 (show IL4 Antibodies)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Antibodies) in Siglec-9 (show SIGLEC9 Antibodies)-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Antibodies) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.

  4. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Antibodies)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) interaction and endotoxemia.

  5. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Antibodies)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  6. depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden.

  7. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Antibodies) activation and ROS (show ROS1 Antibodies) production

  8. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Antibodies)-expressing tumor in the transgenic mice.

  9. Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase (show CASP3 Antibodies) activity.

  10. Sialic acid-binding Ig-like lectin-F (Siglec-F) in mice and its functional paralog Siglec-8 (show SIGLEC8 Antibodies) in humans are transmembrane receptors that play a role in the apoptosis of eosinophils.

SIGLEC5 Antigen Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig-like lectin 5 (SIGLEC5) antibody
  • sialic acid binding Ig-like lectin 5 (Siglec5) antibody
  • sialic acid binding Ig-like lectin E (Siglece) antibody
  • CD33L2 antibody
  • Cd170 antibody
  • mSiglec-E antibody
  • mSiglec-F antibody
  • OB-BP2 antibody
  • OBBP2 antibody
  • SIGLEC-5 antibody
  • Siglec5 antibody
  • Siglec9 antibody
  • Siglec12 antibody
  • Siglecf antibody
  • Siglecl1 antibody

Protein level used designations for SIGLEC5

sialic acid binding Ig-like lectin 5 , CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin F , sialic acid-binding Ig-like lectin F , sialic acid-binding lectin Siglec-F , siglec-5 , siglec-F , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-E , siglec-L1

GENE ID SPECIES
100597560 Nomascus leucogenys
8778 Homo sapiens
233186 Mus musculus
292843 Rattus norvegicus
83382 Mus musculus
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