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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC6 Proteins (9) and SIGLEC6 Kits (3) and many more products for this protein.
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Human Polyclonal SIGLEC6 Primary Antibody for EIA - ABIN357145
Takei, Sasaki, Fujiwara, Takahashi, Muto, Nakamura: Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. in Cytogenetics and cell genetics 1998
Show all 2 references for ABIN357145
Human Polyclonal SIGLEC6 Primary Antibody for EIA, IHC (p) - ABIN357146
Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. in The Journal of biological chemistry 1999
Show all 2 references for ABIN357146
Human Monoclonal SIGLEC6 Primary Antibody for FACS - ABIN4897052
Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. in Scientific reports 2016
Human Polyclonal SIGLEC6 Primary Antibody for WB - ABIN2777065
Brinkman-Van der Linden, Hurtado-Ziola, Hayakawa, Wiggleton, Benirschke, Varki, Varki: Human-specific expression of Siglec-6 in the placenta. in Glycobiology 2007
Siglec6 and leptin (show LEP Antibodies) play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion.
Siglec-6 expression is increased in preterm preeclampsia placentas.
GdA (show PAEP Antibodies) interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK (show EPHB2 Antibodies)/c-Jun (show JUN Antibodies) signaling pathway.
the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process
Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
sialic acid binding Ig-like lectin 6
, CD33 antigen-like 1
, obesity-binding protein 1
, sialic acid-binding Ig-like lectin 6