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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC6 Antibodies (95) and SIGLEC6 Kits (3) and many more products for this protein.
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Human SIGLEC6 Protein expressed in HEK-293 Cells - ABIN2181763
Takei, Sasaki, Fujiwara, Takahashi, Muto, Nakamura: Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. in Cytogenetics and cell genetics 1998
Show all 2 references for ABIN2181763
Siglec6 and leptin (show LEP Proteins) play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion.
Siglec-6 expression is increased in preterm preeclampsia placentas.
GdA (show PAEP Proteins) interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK (show EPHB2 Proteins)/c-Jun (show JUN Proteins) signaling pathway.
the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process
Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
sialic acid binding Ig-like lectin 6
, CD33 antigen-like 1
, obesity-binding protein 1
, sialic acid-binding Ig-like lectin 6