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anti-Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Antibodies

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping Sialic Acid Binding Ig-Like Lectin 7 Proteins (11) and Sialic Acid Binding Ig-Like Lectin 7 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC7 27036 Q9Y286
SIGLEC7    
SIGLEC7    
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Top anti-Sialic Acid Binding Ig-Like Lectin 7 Antibodies at antibodies-online.com

Showing 10 out of 204 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC7 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC7 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-DSiglec C-term H422 Pab (ABIN388430) is used in Western blot to detect DSiglec in Jurkat cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-SIGLEC7 Pab (ABIN388428) in NCI-H460 cell line lysate (35 µg/lane). SIGLEC7(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse PE FACS 100 Tests Log in to see 8 to 10 Days
$522.50
Details
Human Mouse PE IF, IP, WB 25 Tests Log in to see 10 to 12 Days
$157.63
Details
Human Mouse APC Func, IP, ELISA, WB 100 Tests Log in to see 10 to 12 Days
$309.81
Details
Human Mouse PE FACS, ICFC 100 Tests Log in to see 10 to 12 Days
$309.81
Details

SIGLEC7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,


Rat (Rattus) ,


Top referenced anti-Sialic Acid Binding Ig-Like Lectin 7 Antibodies

  1. Human Monoclonal SIGLEC7 Primary Antibody for IF, IP - ABIN2663371 : Brunetta, Fogli, Varchetta, Bozzo, Hudspeth, Marcenaro, Moretta, Mavilio: The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. in Blood 2009 (PubMed)
    Show all 5 references for ABIN2663371

  2. Human Polyclonal SIGLEC7 Primary Antibody for EIA, IHC (p) - ABIN357160 : Nicoll, Avril, Lock, Furukawa, Bovin, Crocker: Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. in European journal of immunology 2003 (PubMed)
    Show all 5 references for ABIN357160

  3. Human Polyclonal SIGLEC7 Primary Antibody for EIA, IHC (p) - ABIN357158 : Alphey, Attrill, Crocker, van Aalten: High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN357158

  4. Human Monoclonal SIGLEC7 Primary Antibody for Func, IP - ABIN2658193 : Yamaji, Mitsuki, Teranishi, Hashimoto: Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. in Glycobiology 2005 (PubMed)
    Show all 3 references for ABIN2658193

  5. Human Monoclonal SIGLEC7 Primary Antibody for FACS, ICFC - ABIN2663372 : Avril, Wagner, Willison, Crocker: Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides. in Infection and immunity 2006 (PubMed)
    Show all 3 references for ABIN2663372

  6. Human Polyclonal SIGLEC7 Primary Antibody for WB - ABIN2782808 : Jaroenpool, Rogers, Pattanapanyasat, Villinger, Onlamoon, Crocker, Ansari: Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. in Cellular immunology 2008 (PubMed)
    Show all 2 references for ABIN2782808

  7. Cow (Bovine) Polyclonal SIGLEC7 Primary Antibody for WB - ABIN2782809 : Braun: The T-cell receptor: just another hypothesis. in Cellular immunology 1976 (PubMed)
    Show all 2 references for ABIN2782809

More Antibodies against Sialic Acid Binding Ig-Like Lectin 7 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) interaction partners

  1. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils.

  2. These results show that Siglec-7 binds HIV-1 via gp120 (show ITIH4 Antibodies) and contributes to enhance the susceptibility to infection of CD4 (show CD4 Antibodies) positive T cells and monocyte-derived macrophages.

  3. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  4. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis.

  5. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition.

  6. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 (show CD33 Antibodies) surface receptors.

  7. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells.

  8. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1

  9. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity

  10. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2.

Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Antigen Profile

Protein Summary

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene names and symbols associated with SIGLEC7

  • sialic acid binding Ig-like lectin 7 (SIGLEC7) antibody
  • AIRM1 antibody
  • CD328 antibody
  • CDw328 antibody
  • D-siglec antibody
  • p75 antibody
  • p75/AIRM1 antibody
  • QA79 antibody
  • SIGLEC-7 antibody
  • SIGLEC7 antibody
  • SIGLEC19P antibody
  • SIGLECP2 antibody

Protein level used designations for SIGLEC7

sialic acid binding Ig-like lectin 7 , AIRM-1 , QA79 membrane protein , adhesion inhibitory receptor molecule 1, siglec-7 , sialic acid binding immunoglobulin-like lectin 7 , sialic acid-binding Ig-like lectin 7

GENE ID SPECIES
468976 Pan troglodytes
100591540 Nomascus leucogenys
27036 Homo sapiens
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