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Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Kits (10) and SIGLEC8 Proteins (7) and many more products for this protein.
Showing 10 out of 64 products:
Human Monoclonal SIGLEC8 Primary Antibody for FACS - ABIN2663883
Nutku, Hudson, Bochner: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. in Biochemical and biophysical research communications 2005
Show all 7 references for ABIN2663883
Human Monoclonal SIGLEC8 Primary Antibody for FACS, ICFC - ABIN2658389
Bochner: Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors. in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009
Show all 4 references for ABIN2658389
Human Polyclonal SIGLEC8 Primary Antibody for EIA, IHC (p) - ABIN357149
Foussias, Yousef, Diamandis: Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene. in Biochemical and biophysical research communications 2000
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Human Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN449557
Nutku, Aizawa, Hudson, Bochner: Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. in Blood 2003
Show all 2 references for ABIN449557
Human Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN565353
von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007
Human Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN308467
Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. in The Journal of allergy and clinical immunology 2008
Ligands for Siglec-8 and Siglec-9 (show SIGLEC9 Antibodies) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (show SIGLEC9 Antibodies) sialoglycan ligands on human airways.
Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (show ARCN1 Antibodies) pathogenesis and may influence COPD (show ARCN1 Antibodies) phenotyping
In activated eosinophils ligation of Siglec-8 leads to ROS (show ROS1 Antibodies)-dependent enhancement of IL-5 (show IL5 Antibodies)-induced ERK (show EPHB2 Antibodies) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.
Engagement of Siglec-8 on blood eosinophils results in caspase (show CASP3 Antibodies)- and mitochondria-dependent apoptosis.
Eosinophils primed by IL-33 (show IL33 Antibodies) and/or IL-5 (show IL5 Antibodies) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.
The Siglec-8 gene may be a susceptibility locus for asthma.
Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3 (show CASP3 Antibodies)-like activity and reduced eosinophil viability through induction of apoptosis
Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl
Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase (show CASP3 Antibodies) cleavage.
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000
, sialic acid-binding Ig-like lectin 8
, sialoadhesin family member 2
, sialic acid binding Ig-like lectin 8