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Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) ELISA Kits

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Antibodies (55) and SIGLEC8 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SIGLEC8 27181 Q9NYZ4
SIGLEC8    
SIGLEC8    
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Top SIGLEC8 ELISA Kits at antibodies-online.com

Showing 5 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.058 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$700.00
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Chicken
  96 Tests Log in to see 8 to 9 Days
$770.00
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Rabbit
  96 Tests Log in to see 8 to 9 Days
$770.00
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Pig
  96 Tests Log in to see 8 to 9 Days
$770.00
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Monkey
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$770.00
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More ELISA Kits for SIGLEC8 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners

  1. Ligands for Siglec-8 and Siglec-9 (show SIGLEC9 ELISA Kits) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  2. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (show SIGLEC9 ELISA Kits) sialoglycan ligands on human airways.

  3. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (show ARCN1 ELISA Kits) pathogenesis and may influence COPD (show ARCN1 ELISA Kits) phenotyping

  4. In activated eosinophils ligation of Siglec-8 leads to ROS (show ROS1 ELISA Kits)-dependent enhancement of IL-5 (show IL5 ELISA Kits)-induced ERK (show EPHB2 ELISA Kits) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  5. Engagement of Siglec-8 on blood eosinophils results in caspase (show CASP3 ELISA Kits)- and mitochondria-dependent apoptosis.

  6. Eosinophils primed by IL-33 (show IL33 ELISA Kits) and/or IL-5 (show IL5 ELISA Kits) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  7. The Siglec-8 gene may be a susceptibility locus for asthma.

  8. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3 (show CASP3 ELISA Kits)-like activity and reduced eosinophil viability through induction of apoptosis

  9. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  10. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase (show CASP3 ELISA Kits) cleavage.

SIGLEC8 Antigen Profile

Antigen Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Gene names and symbols associated with SIGLEC8

  • sialic acid binding Ig-like lectin 8 (SIGLEC8) antibody
  • SAF2 antibody
  • SIGLEC-8 antibody
  • SIGLEC8 antibody
  • SIGLEC8L antibody

Protein level used designations for SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPECIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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