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Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Antibodies (43) and SIGLEC8 Kits (10) and many more products for this protein.
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Human SIGLEC8 Protein expressed in Wheat germ - ABIN1320000
von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007
Ligands for Siglec-8 and Siglec-9 (show SIGLEC9 Proteins) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (show SIGLEC9 Proteins) sialoglycan ligands on human airways.
Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (show ARCN1 Proteins) pathogenesis and may influence COPD (show ARCN1 Proteins) phenotyping
In activated eosinophils ligation of Siglec-8 leads to ROS (show ROS1 Proteins)-dependent enhancement of IL-5 (show IL5 Proteins)-induced ERK (show EPHB2 Proteins) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.
Engagement of Siglec-8 on blood eosinophils results in caspase (show CASP3 Proteins)- and mitochondria-dependent apoptosis.
Eosinophils primed by IL-33 (show IL33 Proteins) and/or IL-5 (show IL5 Proteins) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.
The Siglec-8 gene may be a susceptibility locus for asthma.
Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3 (show CASP3 Proteins)-like activity and reduced eosinophil viability through induction of apoptosis
Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl
Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase (show CASP3 Proteins) cleavage.
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000
, sialic acid-binding Ig-like lectin 8
, sialoadhesin family member 2
, sialic acid binding Ig-like lectin 8