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Sialic Acid Binding Ig-Like Lectin 8 Proteins (SIGLEC8)

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Antibodies (62) and SIGLEC8 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC8 27181 Q9NYZ4
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Top SIGLEC8 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 9 to 11 Days
$774.40
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SIGLEC8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

Top referenced SIGLEC8 Proteins

  1. Human SIGLEC8 Protein expressed in Wheat germ - ABIN1320000 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007 (PubMed)

More Proteins for Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners

  1. Ligands for Siglec-8 and Siglec-9 (show SIGLEC9 Proteins) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  2. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (show SIGLEC9 Proteins) sialoglycan ligands on human airways.

  3. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (show ARCN1 Proteins) pathogenesis and may influence COPD (show ARCN1 Proteins) phenotyping

  4. In activated eosinophils ligation of Siglec-8 leads to ROS (show ROS1 Proteins)-dependent enhancement of IL-5 (show IL5 Proteins)-induced ERK (show EPHB2 Proteins) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  5. Engagement of Siglec-8 on blood eosinophils results in caspase (show CASP3 Proteins)- and mitochondria-dependent apoptosis.

  6. Eosinophils primed by IL-33 (show IL33 Proteins) and/or IL-5 (show IL5 Proteins) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  7. The Siglec-8 gene may be a susceptibility locus for asthma.

  8. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3 (show CASP3 Proteins)-like activity and reduced eosinophil viability through induction of apoptosis

  9. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  10. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase (show CASP3 Proteins) cleavage.

SIGLEC8 Protein Profile

Protein Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Gene names and symbols associated with SIGLEC8

  • sialic acid binding Ig-like lectin 8 (SIGLEC8)
  • SAF2 protein
  • SIGLEC-8 protein
  • SIGLEC8 protein
  • SIGLEC8L protein

Protein level used designations for SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPECIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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