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anti-Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Antibodies

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC9 Proteins (6) and SIGLEC9 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC9 27180 Q9Y336
SIGLEC9 83382 Q91Y57
SIGLEC9    
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Top anti-SIGLEC9 Antibodies at antibodies-online.com

Showing 10 out of 132 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC9 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SIGLEC9 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SIGLEC9 antibody detected the SIGLEC9 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC9 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC9. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Dog Mouse Un-conjugated IHC, WB Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-SIGLEC9mouse monoclonal antibody. (ABIN2452510, Dilution 1:50) Immunohistochemical staining of paraffin-embedded liver tissue using anti-SIGLEC9mouse monoclonal antibody. (ABIN2452510, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-SIGLEC9 mouse monoclonal antibody. (ABIN2452496, Dilution 1:50) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC9 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC9. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$266.33
Details
Human Mouse APC FACS, IF, ICFC 100 Tests Log in to see 10 to 12 Days
$309.81
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Siglec9 C-term Pab (ABIN388422) is used in Western blot to detect Siglec9 in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using SIGLEC9, antibody at 1:100 dilution. WB Image Sample(30 ug whole cell lysate) A:Hep G2 , B:MOLT4 , 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details

SIGLEC9 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) ,


Dog (Canine)
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Top referenced anti-SIGLEC9 Antibodies

  1. Human Polyclonal SIGLEC9 Primary Antibody for EIA, IHC (p) - ABIN357151 : Zhang, Nicoll, Jones, Crocker: Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. in The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for ABIN357151

  2. Human Monoclonal SIGLEC9 Primary Antibody for FACS, IF - ABIN2658391 : Ikehara, Ikehara, Paulson: Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN2658391

  3. Human Monoclonal SIGLEC9 Primary Antibody for FACS - ABIN2662845 : von Gunten, Yousefi, Seitz, Jakob, Schaffner, Seger, Takala, Villiger, Simon: Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. in Blood 2005 (PubMed)
    Show all 3 references for ABIN2662845

More Antibodies against SIGLEC9 Interaction Partners

Chimpanzee Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.

Human Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. Ligands for Siglec-8 (show SIGLEC8 Antibodies) and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  2. Inflammation results in up-regulation of immuneinhibitory Siglec-8 (show SIGLEC8 Antibodies) and Siglec-9 sialoglycan ligands on human airways.

  3. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung ca (show CD33 Antibodies)ncer patients

  4. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3 (show CD33 Antibodies).

  5. Expression of Siglec-7 (show SIGLEC7 Antibodies) and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  6. Protein degradation of focal adhesion kinase and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells.

  7. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Antibodies) and that this signaling may be another MUC1 (show MUC1 Antibodies)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. The Siglec-9 peptide binding to the enzymatic groove of VAP-1 (show AOC3 Antibodies) can be used for imaging conditions, such as inflammation and cancer.

  9. Siglec-9 A391C was the only polymorphism related to TCR-mediated signaling in human Siglec-9, resulting in less inhibition compared to the wild type.

  10. These results suggest that Siglec-9 expressed on DCs is involved in immunoregulation through ligation with mucins in an epithelial cancer patient.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) interaction partners

  1. indicate that Siglec-9 affects several different signaling pathways in IL-4 (show IL4 Antibodies)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Antibodies) in Siglec-9-expressing RAW264 cells

  2. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Antibodies) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  3. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Antibodies)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) interaction and endotoxemia.

  4. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Antibodies)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  5. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Antibodies) activation and ROS (show ROS1 Antibodies) production

  6. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Antibodies)-expressing tumor in the transgenic mice.

  7. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Antibodies) and that this signaling may be another MUC1 (show MUC1 Antibodies)-mediated pathway and function in parallel with a growth factor-dependent pathway.

  8. Siglec-E is induced in a MyD88 (show MYD88 Antibodies)-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB (show NFKB1 Antibodies) antiviral responses by directly inhibiting TLR-induced antiviral cytokine production.

SIGLEC9 Antigen Profile

Protein Summary

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene names and symbols associated with SIGLEC9

  • sialic acid-binding immunoglobulin-like lectin 9 (siglec9) antibody
  • sialic acid binding Ig-like lectin 9 (SIGLEC9) antibody
  • sialic acid binding Ig-like lectin E (Siglece) antibody
  • Cd170 antibody
  • CD329 antibody
  • CDw329 antibody
  • FOAP-9 antibody
  • mSiglec-E antibody
  • OBBP-LIKE antibody
  • siglec-9 antibody
  • Siglec5 antibody
  • Siglec9 antibody
  • Siglec12 antibody
  • Siglecl1 antibody

Protein level used designations for SIGLEC9

sialic acid-binding immunoglobulin-like lectin 9 , sialic acid binding Ig-like lectin 9 , protein FOAP-9 , sialic acid-binding Ig-like lectin 9 , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-5 , siglec-E , siglec-L1

GENE ID SPECIES
497116 Pan troglodytes
100610476 Pan troglodytes
27180 Homo sapiens
83382 Mus musculus
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