Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin Proteins (SIGLEC1)

SIGLEC1 encodes a member of the immunoglobulin superfamily. Additionally we are shipping SIGLEC1 Antibodies (233) and SIGLEC1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC1 20612 Q62230
SIGLEC1 6614 Q9BZZ2
Rat SIGLEC1 SIGLEC1 311426  
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Top SIGLEC1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$544.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$749.38
Details

SIGLEC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Interaction Partners

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. CD169(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (show CD8A Proteins)(+) T-cell exhaustion and immunopathology.

  2. Although CD169 participates in the immune response to tumour antigen and appears to be a positive prognostic marker for human cancers, its role in modulating melanoma growth and metastasis is less clear.

  3. Inhibition of Siglec-1 can prevent atherosclerotic lesion formation by suppress monocytes-endothelial cells adhesion and macrophages accumulation.

  4. Data show that knockdown of sialic acid binding Ig-like lectin 1 (siglec-1) in RAW 264.7 macrophage resulted in inhibiting the production of transforming growth factor beta 1 (TGF-beta1 (show TGFB1 Proteins)) production.

  5. Viral infection significantly upregulated Siglec1 expression in mouse macrophages in an IFN/JAK (show JAK3 Proteins)/STAT1 (show STAT1 Proteins) pathway-dependent manner.

  6. Siglec-1 is a key receptor for macrophage/lymphocyte trans-infection of surface-bound virions, and the N-acyl side chain of sialic acid is a critical determinant for the Siglec-1/MLV interaction.

  7. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread.

  8. CD169(+) monocytes and macrophages have a critical role in preventing excessive inflammation in renal ischemia-reperfusion injury by downregulating intercellular adhesion molecule-1 (show ICAM1 Proteins) expression on vascular endothelial cells.

  9. results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses

  10. Sialoadhesin is critical for macrophages to phagocytose and clear the sialylated pathogen group B Streptococcus.

Human Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid-binding immunoglobulin-like lectin.

  2. High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A (show TRIM21 Proteins) indicates an enhanced risk for autoimmune congenital heart block development.

  3. These data demonstrate a prominent role for Siglec-1 in the internalization of HIV-1 to the virus-containing compartment in infected monocyte-derived macrophages

  4. These findings suggest that CD169+ macrophages in RLNs might be a useful marker for assessing clinical stage, including LN states, in patients with breast cancer.

  5. CD169 might act as a co-stimulatory molecule for cytotoxic T-cell activation, and could define a population of tumour-infiltrating macrophages with potential anti-tumour properties in human hepatocellular carcinoma tissues.

  6. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the lymph node sinus was a predictive factor for better clinical prognosis.

  7. Siglec-1 and Siglec-2 (show CD22 Proteins) are potential biomarkers in autoimmune disease. (Review)

  8. Siglec-1 on myeloid cells could fuel novel CD4 (show CD4 Proteins)(+) T-cell infections and contribute to HIV-1 dissemination in vivo.

  9. evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells

  10. Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses

Pig (Porcine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) interaction partners

  1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end.

  2. Fusion protein of sialoadhesin and domains 5-9 of CD163 (show CD163 Proteins) receptors blocked the respiratory syndrome virus infection.

  3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin.

  4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology.

  5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently.

  6. ). These results provided fundamental evidence for CD163 (show CD163 Proteins) and SN as two functional candidate genes affecting immunity in pigs.

  7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production

  8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.

  9. Sialoadhesin is confirmed as a PRRSV (porcine reproductive and respiratory syndrome virus)internalization receptor and is shown to interact with CD163 (show CD163 Proteins) in PRRSV entry.

  10. Clear changes in the quantity of sialoadhesin(+) and CD163 (show CD163 Proteins)(+) macrophages in the placentas and organs of embryos/fetuses during gestation.

SIGLEC1 Protein Profile

Protein Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound\; however, the full-length nature of this variant has not been determined.

Gene names and symbols associated with SIGLEC1

  • sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1)
  • sialoadhesin (LOC100345836)
  • sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1)
  • sialoadhesin (SIGLEC-1)
  • CD169 protein
  • dJ1009E24.1 protein
  • p210 protein
  • pSn protein
  • SA protein
  • SIGLEC-1 protein
  • SIGLEC1 protein
  • SN protein

Protein level used designations for SIGLEC1

sialoadhesin , SER , sheep erythrocyte receptor , sialic acid-binding Ig-like lectin 1 , sialic acid-binding immunoglobulin-like lectin 1 , Sialic acid-binding Ig-like lectin 1

GENE ID SPECIES
469866 Pan troglodytes
100345836 Oryctolagus cuniculus
20612 Mus musculus
6614 Homo sapiens
311426 Rattus norvegicus
539759 Bos taurus
397623 Sus scrofa
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