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Binds sialylated glycoproteins.. Additionally we are shipping SIGLEC15 Proteins (2) and many more products for this protein.
Showing 10 out of 28 products:
Human Polyclonal SIGLEC15 Primary Antibody for EIA, IF - ABIN1450134
Crocker, Redelinghuys: Siglecs as positive and negative regulators of the immune system. in Biochemical Society transactions 2008
Show all 4 references for ABIN1450134
Human Polyclonal SIGLEC15 Primary Antibody for EIA, WB - ABIN954806
Angata, Tabuchi, Nakamura, Nakamura: Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. in Glycobiology 2007
Siglec-15 recognizes the tumoral sTn (show EEF1A2 Antibodies) antigen and transduces a signal for enhanced TGF-beta (show TGFB1 Antibodies) secretion in TAMs
Siglec-15 does not mediate joint destruction in inflammatory arthritis
The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.
Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL (show TNFSF11 Antibodies)) signaling in association with DAP12 (show TYROBP Antibodies).
DC-STAMP (show TM7SF4 Antibodies), Siglec-15, Tspan7 (show TSPAN7 Antibodies) and Mst1r (show MST1R Antibodies) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
results reveal the importance of Siglec-15 in the regulation of osteoclast formation and/or function in vivo, providing new insights into osteoclast biology
the Siglec-15-DAP12 (show TYROBP Antibodies)-Syk (show SYK Antibodies)-signaling cascade plays a critical role in functional osteoclast formation.
These results suggest that Siglec-15 plays an important role in osteoclast differentiation.
Binds sialylated glycoproteins.
sialic acid-binding Ig-like lectin 15
, CD33 antigen-like 3
, CD33 molecule-like 3