anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Antibodies

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Proteins (19) and SIGLEC5 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC5 8778 O15389
SIGLEC5 233186 Q920G3
SIGLEC5 292843  
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Top anti-SIGLEC5 Antibodies at antibodies-online.com

Showing 10 out of 167 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CD170 / SIGLEC5 Antibody  in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Fluorescein FACS Detection of Siglec-5/Siglec-14 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human Siglec-5/Siglec-14 Fluorescein-conjugated Monoclonal Antibody. Detection of Siglec-5/Siglec-14 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human Siglec-5/Siglec-14 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$262.50
Details
Human Mouse Un-conjugated ELISA (Capture), FACS, Neut Cell Adhesion Mediated by Siglec-5 and Neutralization by Human Siglec-5/14 Antibody. Recombinant Human Siglec-5 Fc Chimera. The ND50 is typically 0.04-0.2 ug/mL. Detection of Siglec-5/14 in Human Monocytes by Flow Cytometry. Human blood derived monocytes were stained with Mouse Anti-Human Siglec-5/14 Monoclonal Antibody. 500 μg Log in to see 8 to 9 Days
$346.50
Details
Human Mouse Allophycocyanin FACS Detection of Siglec-5/Siglec-14 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human Siglec-5/Siglec-14 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$357.00
Details
Human Goat Un-conjugated FACS, IHC, Neut, WB Cell Adhesion Mediated by Siglec-5 and Neutralization by Human Siglec-5/14 Antibody. Recombinant Human Siglec-5 Fc Chimera. The ND50 is typically 0.5-2.0 ug/mL. Detection of Siglec-5/14 in Human Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Human Siglec-5/14 Antigen Affinity-purified Polyclonal Antibody. 100 μg Log in to see 8 to 9 Days
$393.75
Details
Human Goat Biotin FACS, WB Detection of Siglec-5 and Siglec-14 in Human Monocytes and Granulocytes by Flow Cytometry. Human whole blood monocytes and granulocytes were stained with Human Siglec-5/14 Biotinylated Antigen Affinity-purified Polyclonal Antibody. Detection of Siglec-5 and Siglec-14 in Human Monocytes and Granulocytes by Flow Cytometry. Human whole blood monocytes and granulocytes were stained with Human Siglec-5/14 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8 to 9 Days
$399.00
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$282.64
Details
Human Mouse APC ELISA 100 Tests Log in to see 10 to 12 Days
$320.68
Details

SIGLEC5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIGLEC5 Antibodies

  1. Human Monoclonal SIGLEC5 Primary Antibody for FACS - ABIN2662475 : Zhuravleva, Trandem, Sun: Structural implications of Siglec-5-mediated sialoglycan recognition. in Journal of molecular biology 2007 (PubMed)
    Show all 7 references for 2662475

  2. Human Monoclonal SIGLEC5 Primary Antibody for ELISA - ABIN2656969 : Soto, Stein, Hurtado-Ziola, Hedrick, Varki: Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for 2656969

  3. Human Polyclonal SIGLEC5 Primary Antibody for EIA, WB - ABIN951208 : Carlin, Chang, Areschoug, Lindahl, Hurtado-Ziola, King, Varki, Nizet: Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. in The Journal of experimental medicine 2009 (PubMed)
    Show all 5 references for 951208

  4. Human Monoclonal SIGLEC5 Primary Antibody for ELISA (Capture), FACS - ABIN4899350 : Gunnarsson, Fornander, Påhlsson, Grenegård: Sialic acid residues play a pivotal role in alpha(1)-acid glycoprotein (AGP)-induced generation of reactive oxygen species in chemotactic peptide pre-activated neutrophil granulocytes. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2010 (PubMed)
    Show all 4 references for 4899350

  5. Human Polyclonal SIGLEC5 Primary Antibody for EIA, IHC (p) - ABIN357143 : Erickson-Miller, Freeman, Hopson, DAlessio, Fischer, Kikly, Abrahamson, Holmes, King: Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. in Experimental hematology 2003 (PubMed)
    Show all 3 references for 357143

  6. Human Monoclonal SIGLEC5 Primary Antibody for FACS - ABIN4895978 : Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. in Immunology letters 2010 (PubMed)
    Show all 3 references for 4895978

  7. Human Polyclonal SIGLEC5 Primary Antibody for EIA, WB - ABIN357144 : Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for 357144

  8. Human Polyclonal SIGLEC5 Primary Antibody for FACS, IHC - ABIN4899306 : Costelloe, Watson, Murphy, McQuillan, Loscher, Armstrong, Garlanda, Mantovani, ONeill, Mills, Lynch: IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. in Journal of neurochemistry 2008 (PubMed)
    Show all 2 references for 4899306

  9. Human Polyclonal SIGLEC5 Primary Antibody for FACS, WB - ABIN4899349 : Zou, Chastain, Moir, Ford, Trandem, Martinelli, Cicala, Crocker, Arthos, Sun: Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. in PLoS ONE 2011 (PubMed)
    Show all 2 references for 4899349

  10. Human Monoclonal SIGLEC5 Primary Antibody for FACS - ABIN4895979 : Ali, Fong, Carlin, Busch, Linden, Angata, Areschoug, Parast, Varki, Murray, Nizet, Varki: Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. in The Journal of experimental medicine 2014 (PubMed)

More Antibodies against SIGLEC5 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. An unbiased screen revealed Hsp70 (show HSP70 Antibodies) as a ligand for Siglec-5 and Siglec-14 (show SIGLEC14 Antibodies). Hsp70 (show HSP70 Antibodies) stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 (show SIGLEC14 Antibodies) is pro-inflammatory.

  2. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  3. we found that secretory IgA is taken up by M cells via the Dectin-1 (show CLEC7A Antibodies) receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  4. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  5. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  6. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  7. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  8. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  9. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  10. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated (show SULF1 Antibodies) oligosaccharides containing sialic acid.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. The Siglec-E-deficient dendritic cells were defective for TRIF (show RNF138 Antibodies)-mediated IFN-beta (show IFNB1 Antibodies) production in response to E. coli infection.

  2. This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (show SIGLEC1 Antibodies).

  3. Immunohistochemical analysis of the Peyer's patches (PPs (show INPP5K Antibodies)) tissue sections shows that Siglec-F is expressed on the surface of the Intestinal microfold (M) cell membrane exposed to the intestinal lumen.

  4. new data relating to the structure and function of Siglec-E, the major CD33 (show CD33 Antibodies)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.

  5. indicate that Siglec-9 (show SIGLEC9 Antibodies) affects several different signaling pathways in IL-4 (show IL4 Antibodies)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Antibodies) in Siglec-9 (show SIGLEC9 Antibodies)-expressing RAW264 cells

  6. Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Antibodies) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  7. These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.

  8. Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Antibodies)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) interaction and endotoxemia.

  9. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Antibodies)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  10. depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden.

SIGLEC5 Antigen Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig-like lectin 5 (SIGLEC5) antibody
  • sialic acid binding Ig-like lectin 5 (Siglec5) antibody
  • sialic acid binding Ig-like lectin E (Siglece) antibody
  • CD33L2 antibody
  • Cd170 antibody
  • mSiglec-E antibody
  • mSiglec-F antibody
  • OB-BP2 antibody
  • OBBP2 antibody
  • SIGLEC-5 antibody
  • Siglec5 antibody
  • Siglec9 antibody
  • Siglec12 antibody
  • Siglecf antibody
  • Siglecl1 antibody

Protein level used designations for SIGLEC5

sialic acid binding Ig-like lectin 5 , CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin F , sialic acid-binding Ig-like lectin F , sialic acid-binding lectin Siglec-F , siglec-5 , siglec-F , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-E , siglec-L1

GENE ID SPECIES
100597560 Nomascus leucogenys
8778 Homo sapiens
233186 Mus musculus
292843 Rattus norvegicus
83382 Mus musculus
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