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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC9 Proteins (7) and SIGLEC9 Kits (3) and many more products for this protein.
Showing 10 out of 158 products:
Human Polyclonal SIGLEC9 Primary Antibody for EIA, IHC (p) - ABIN357151
Zhang, Nicoll, Jones, Crocker: Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. in The Journal of biological chemistry 2000
Show all 5 references for 357151
Human Monoclonal SIGLEC9 Primary Antibody for FACS - ABIN4895961
Béziat, Dalgard, Asselah, Halfon, Bedossa, Boudifa, Hervier, Theodorou, Martinot, Debré, Björkström, Malmberg, Marcellin, Vieillard: CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients. in European journal of immunology 2012
Show all 3 references for 4895961
Human Polyclonal SIGLEC9 Primary Antibody for FACS, ICC - ABIN4899346
Ando, Tu, Nishijima, Iijima: Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs. in Biochemical and biophysical research communications 2008
Human Polyclonal SIGLEC9 Primary Antibody for ELISA (Detection), FACS - ABIN4899343
Zou, Chastain, Moir, Ford, Trandem, Martinelli, Cicala, Crocker, Arthos, Sun: Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. in PLoS ONE 2011
Human Monoclonal SIGLEC9 Primary Antibody for ELISA (Capture), FACS - ABIN4899344
Carlin, Uchiyama, Chang, Lewis, Nizet, Varki: Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. in Blood 2009
Human Polyclonal SIGLEC9 Primary Antibody for WB - ABIN2782811
von Gunten, Yousefi, Seitz, Jakob, Schaffner, Seger, Takala, Villiger, Simon: Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. in Blood 2005
Human Monoclonal SIGLEC9 Primary Antibody for FACS - ABIN4895965
Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. in Scientific reports 2016
Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.
Glycophorin A (show GYPA Antibodies), the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood.
Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA).
The mechanism of the Siglec-9 and AOC3 (show AOC2 Antibodies) interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain.
This work defines a critical role for aberrantly glycosylated MUC1 (show MUC1 Antibodies) and identifies an activating pathway that follows engagement of Siglec-9.
Constitutively expressed Siglec-9 inhibits LPS (show IRF6 Antibodies)-induced CCR7 (show CCR7 Antibodies), but enhances IL-4 (show IL4 Antibodies)-induced CD200R (show CD200R1 Antibodies) expression in human macrophages.
Ligands for Siglec-8 (show SIGLEC8 Antibodies) and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
Inflammation results in up-regulation of immuneinhibitory Siglec-8 (show SIGLEC8 Antibodies) and Siglec-9 sialoglycan ligands on human airways.
a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung ca (show CD33 Antibodies)ncer patients
Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3 (show CD33 Antibodies).
Expression of Siglec-7 (show SIGLEC7 Antibodies) and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.
This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (show SIGLEC1 Antibodies).
new data relating to the structure and function of Siglec-E, the major CD33 (show CD33 Antibodies)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.
indicate that Siglec-9 affects several different signaling pathways in IL-4 (show IL4 Antibodies)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Antibodies) in Siglec-9-expressing RAW264 cells
Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 Antibodies) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment
Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Antibodies)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) interaction and endotoxemia.
Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 Antibodies)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.
siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 Antibodies) activation and ROS (show ROS1 Antibodies) production
These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 Antibodies)-expressing tumor in the transgenic mice.
Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 Antibodies) and that this signaling may be another MUC1 (show MUC1 Antibodies)-mediated pathway and function in parallel with a growth factor-dependent pathway.
Siglec-E is induced in a MyD88 (show MYD88 Antibodies)-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB (show NFKB1 Antibodies) antiviral responses by directly inhibiting TLR-induced antiviral cytokine production.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
sialic acid-binding immunoglobulin-like lectin 9
, sialic acid binding Ig-like lectin 9
, protein FOAP-9
, sialic acid-binding Ig-like lectin 9
, SIGLEC-like 1
, myeloid inhibitory siglec
, sialic acid binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin 12
, sialic acid-binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin E
, sialic acid-binding Ig-like lectin-like 1
, sialic acid-binding immunoglobulin-like lectin E