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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping SIGLEC9 Antibodies (172) and SIGLEC9 Proteins (7) and many more products for this protein.
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Human SIGLEC9 ELISA Kit for Sandwich ELISA - ABIN625353
Matsubara, Matsushita, Sakai, Kano, Kondo, Noda, Hashimoto, Imagama, Ishiguro, Suzumura, Ueda, Furukawa, Yamamoto: Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Show all 2 Pubmed References
Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.
Glycophorin A (show GYPA ELISA Kits), the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood.
Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA).
The mechanism of the Siglec-9 and AOC3 (show AOC2 ELISA Kits) interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain.
This work defines a critical role for aberrantly glycosylated MUC1 (show MUC1 ELISA Kits) and identifies an activating pathway that follows engagement of Siglec-9.
Constitutively expressed Siglec-9 inhibits LPS (show IRF6 ELISA Kits)-induced CCR7 (show CCR7 ELISA Kits), but enhances IL-4 (show IL4 ELISA Kits)-induced CD200R (show CD200R1 ELISA Kits) expression in human macrophages.
Ligands for Siglec-8 (show SIGLEC8 ELISA Kits) and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
Inflammation results in up-regulation of immuneinhibitory Siglec-8 (show SIGLEC8 ELISA Kits) and Siglec-9 sialoglycan ligands on human airways.
a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung ca (show CD33 ELISA Kits)ncer patients
Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3 (show CD33 ELISA Kits).
Expression of Siglec-7 (show SIGLEC7 ELISA Kits) and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.
The Siglec-E-deficient dendritic cells were defective for TRIF (show RNF138 ELISA Kits)-mediated IFN-beta (show IFNB1 ELISA Kits) production in response to E. coli infection.
This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (show SIGLEC1 ELISA Kits).
new data relating to the structure and function of Siglec-E, the major CD33 (show CD33 ELISA Kits)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.
indicate that Siglec-9 affects several different signaling pathways in IL-4 (show IL4 ELISA Kits)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 ELISA Kits) in Siglec-9-expressing RAW264 cells
Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 ELISA Kits) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment
Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 ELISA Kits)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits)) interaction and endotoxemia.
Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 ELISA Kits)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.
siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 ELISA Kits) activation and ROS (show ROS1 ELISA Kits) production
These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 ELISA Kits)-expressing tumor in the transgenic mice.
Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 ELISA Kits) and that this signaling may be another MUC1 (show MUC1 ELISA Kits)-mediated pathway and function in parallel with a growth factor-dependent pathway.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
sialic acid-binding immunoglobulin-like lectin 9
, sialic acid binding Ig-like lectin 9
, protein FOAP-9
, sialic acid-binding Ig-like lectin 9
, SIGLEC-like 1
, myeloid inhibitory siglec
, sialic acid binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin 12
, sialic acid-binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin E
, sialic acid-binding Ig-like lectin-like 1
, sialic acid-binding immunoglobulin-like lectin E