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anti-Signal Peptide Peptidase 3 (SPPL3) Antibodies

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat SPPL3 SPPL3 360822  
Anti-Mouse SPPL3 SPPL3 74585 Q9CUS9
SPPL3 121665 Q8TCT6
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Top anti-SPPL3 Antibodies at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA Western blot analysis of SPPL3(arrow) using rabbit polyclonal SPPL3 Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SPPL3(arrow) using rabbit polyclonal SPPL3 Antibody (N-term) (ABIN390296). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SPPL3 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

SPPL3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,


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Top referenced anti-SPPL3 Antibodies

  1. Human Polyclonal SPPL3 Primary Antibody for EIA - ABIN358855 : Grigorenko, Moliaka, Korovaitseva, Rogaev: Novel class of polytopic proteins with domains associated with putative protease activity. in Biochemistry. Biokhimii?a 2002 (PubMed)
    Show all 2 references for ABIN358855

More Antibodies against SPPL3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Signal Peptide Peptidase 3 (SPPL3) interaction partners

  1. Expression and characterization of signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.

Zebrafish Signal Peptide Peptidase 3 (SPPL3) interaction partners

  1. SPPL2b (show SPPL2B Antibodies) is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (show HM13 Antibodies) and SPPL3 are restricted to the ER.

Mouse (Murine) Signal Peptide Peptidase 3 (SPPL3) interaction partners

  1. Our results identify SPPL3 as a cell-autonomous molecular determinant of NK cell maturation

Human Signal Peptide Peptidase 3 (SPPL3) interaction partners

  1. SPPL3 substrates identified on a proteome-wide scale in human and murine cells include numerous glycan-modifying enzymes residing in the Golgi network and implicated in distinct glycosylation pathways, including N-glycosylation, mucin (show SLC13A2 Antibodies)-type O-glycosylation, O-mannosylation and glycosaminoglycan biosynthesis.

  2. SPPL3 cleaves Golgi type II membrane proteins leading to their secretion. SPPL3 substrates include Golgi glycosyltransferases MGAT5 (show MGAT5 Antibodies), B4GALT1 (show B4GALT1 Antibodies), and B3GNT1 (show B3GNT2 Antibodies). By facilitating disengagement of these glycosyltransferases from their membrane anchors, SPPL3 causes their premature secretion and consequently orchestrates the extent of N-glycosylation on human and murine cells.

  3. SPPL3 enhances the signal-induced association of stromal interaction molecule 1 (show STIM1 Antibodies)

  4. human SPPL3 is the first GxGD-type aspartyl protease (show REN1 Antibodies) shown to be capable of acting like a sheddase, similar to members of the rhomboid family, which belong to the class of intramembrane-cleaving serine proteases.

  5. SPP (show SPEB Antibodies), SPPL2a (show SPPL2A Antibodies), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  6. SPPL2b (show SPPL2B Antibodies) is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (show SPEB Antibodies) and SPPL3 are restricted to the ER.

  7. SPPL3 cleaves a SPP (show SPEB Antibodies) substrate, but a more distantly related homologue SPPL2b (show SPPL2B Antibodies) does not, providing strong evidence that the malaria SPP (show SPEB Antibodies) and human SPPL3 have conserved active sites, while the active sites SPPL2b (show SPPL2B Antibodies) is distinct

SPPL3 Antigen Profile

Protein Summary

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.

Gene names and symbols associated with SPPL3

  • Signal peptide peptidase-like (SppL) antibody
  • signal peptide peptidase like 3 (Sppl3) antibody
  • signal peptide peptidase 3 (sppl3) antibody
  • signal peptide peptidase 3 (SPPL3) antibody
  • Protein IMP-2 (imp-2) antibody
  • signal peptide peptidase 3 (Sppl3) antibody
  • signal peptide peptidase like 3 (SPPL3) antibody
  • 4833416I09Rik antibody
  • CG5901 antibody
  • CG17370 antibody
  • Dmel\\CG17370 antibody
  • fb94d08 antibody
  • IMP2 antibody
  • MDHV1887 antibody
  • MGC52975 antibody
  • MGC75937 antibody
  • PRO4332 antibody
  • PSH1 antibody
  • PSL4 antibody
  • RGD1562826 antibody
  • sppL antibody
  • sppl3 antibody
  • Sppl3-ps1 antibody
  • Usmg3 antibody
  • wu:fb94d08 antibody
  • zgc:114093 antibody

Protein level used designations for SPPL3

CG17370-PA , CG17370-PB , CG17370-PC , CG17370-PD , CG17370-PE , SPP-like protein 3 , SppL-PA , SppL-PB , SppL-PC , SppL-PD , SppL-PE , signal peptide peptidase-like , signal peptide peptidase 3 , signal peptide peptidase-like 3 , signal peptide peptidase-like 3, pseudogene 1 , signal peptide protease-like , signal peptide peptidase-like protein 3 , IMP-2 , SPP-like 3 protein , intramembrane protease 2 , presenilin-like protein 4 , upregulated during skeletal muscle growth 3 , SPP-like 3 , presenilin homologous protein 1

GENE ID SPECIES
43128 Drosophila melanogaster
360822 Rattus norvegicus
379304 Xenopus laevis
394539 Xenopus (Silurana) tropicalis
535156 Bos taurus
548609 Danio rerio
700898 Macaca mulatta
178013 Caenorhabditis elegans
74585 Mus musculus
121665 Homo sapiens
Selected quality suppliers for anti-SPPL3 (SPPL3) Antibodies
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