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anti-Signal Peptide Peptidase-Like 2A (SPPL2A) Antibodies

SPPL2A encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. Additionally we are shipping SPPL2A Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPPL2A 311401  
SPPL2A 84888 Q8TCT8
SPPL2A 66552 Q9JJF9
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Top anti-SPPL2A Antibodies at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SPPL2a Pab (ABIN390295) is used in Western blot to detect SPPL2a in Jurkat cell lysate. Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term)(ABIN390295), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. The anti-SPPL2a Pab is used in Western blot to detect SPPL2a in Jurkat cell lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SPPL2A is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

SPPL2A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,
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Mouse (Murine)


More Antibodies against SPPL2A Interaction Partners

Human Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. In human B cells, SPPL2a is indispensable for turnover of CD74 (show CD74 Antibodies) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein.

  2. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  3. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

  4. SPP (show SPEB Antibodies), SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  5. ADAM10 (show ADAM10 Antibodies) and SPPL2a were identified as two proteases implicated in FasL (show FASL Antibodies) processing and release of the FasL (show FASL Antibodies) intracellular domain, which has been shown to be important for retrograde FasL (show FASL Antibodies) signaling

  6. SPPL2a and SPPL2b (show SPPL2B Antibodies) mediate the intramembrane cleavage, whereas neither SPP (show SPEB Antibodies) nor SPPL3 (show SPPL3 Antibodies) is capable of processing the Bri2 (show ITM2B Antibodies) N-terminal fragment.

Mouse (Murine) Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. SPPL2a-mediated processing of CD74 (show CD74 Antibodies) NTF (show TNF Antibodies) is indispensable to maintain appropriate levels of tonic BCR (show BCR Antibodies) signaling to promote B cell maturation (show TNFRSF17 Antibodies).

  2. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  3. in vivo SPPL2a, but not SPPL2b (show SPPL2B Antibodies), exhibit a physiologically relevant contribution to CD74 (show CD74 Antibodies) proteolysis in B and dendritic cells

  4. intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts.

  5. Sppl2a is required for B cell and dendritic cells development and survival.

  6. Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

  7. B cell survival and dendritic cells function requires SPPL2A.

  8. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

SPPL2A Antigen Profile

Protein Summary

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

Gene names and symbols associated with SPPL2A

  • signal peptide peptidase-like 2A (Sppl2a) antibody
  • signal peptide peptidase-like 2A (RCJMB04_13a21) antibody
  • signal peptide peptidase-like 2A (LOC453430) antibody
  • signal peptide peptidase-like 2A (sppl2a) antibody
  • signal peptide peptidase-like 2A (LOC100231183) antibody
  • signal peptide peptidase-like 2A (LOC100348259) antibody
  • Signal peptide peptidase-like 2A (psl2) antibody
  • signal peptide peptidase like 2A (SPPL2A) antibody
  • signal peptide peptidase like 2A (Sppl2a) antibody
  • 2010106G01Rik antibody
  • C130089K23Rik antibody
  • IMP3 antibody
  • LOC453430 antibody
  • LOC100231183 antibody
  • PSL2 antibody
  • RGD1563001 antibody
  • SPPL2A antibody

Protein level used designations for SPPL2A

signal peptide peptidase-like 2A , Signal peptide peptidase-like 2A , IMP-3 , SPP-like 2A , intramembrane cleaving protease , intramembrane protease 3 , presenilin-like protein 2 , SPP-like 2A protein , protein SPPL2a

GENE ID SPECIES
311401 Rattus norvegicus
415450 Gallus gallus
453430 Pan troglodytes
100135083 Xenopus (Silurana) tropicalis
100231183 Taeniopygia guttata
100348259 Oryctolagus cuniculus
100380541 Salmo salar
84888 Homo sapiens
66552 Mus musculus
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