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Signal Peptide Peptidase-Like 2A Proteins (SPPL2A)

SPPL2A encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. Additionally we are shipping SPPL2A Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SPPL2A SPPL2A 311401  
SPPL2A 84888 Q8TCT8
SPPL2A 66552 Q9JJF9
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Top SPPL2A Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SPPL2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Signal Peptide Peptidase-Like 2A (SPPL2A) Interaction Partners

Human Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. In human B cells, SPPL2a is indispensable for turnover of CD74 (show CD74 Proteins) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein.

  2. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  3. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

  4. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  5. ADAM10 (show ADAM10 Proteins) and SPPL2a were identified as two proteases implicated in FasL (show FASL Proteins) processing and release of the FasL (show FASL Proteins) intracellular domain, which has been shown to be important for retrograde FasL (show FASL Proteins) signaling

  6. SPPL2a and SPPL2b (show SPPL2B Proteins) mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B Proteins) N-terminal fragment.

Mouse (Murine) Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. SPPL2a-mediated processing of CD74 (show CD74 Proteins) NTF (show TNF Proteins) is indispensable to maintain appropriate levels of tonic BCR (show BCR Proteins) signaling to promote B cell maturation (show TNFRSF17 Proteins).

  2. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  3. in vivo SPPL2a, but not SPPL2b (show SPPL2B Proteins), exhibit a physiologically relevant contribution to CD74 (show CD74 Proteins) proteolysis in B and dendritic cells

  4. intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts.

  5. Sppl2a is required for B cell and dendritic cells development and survival.

  6. Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

  7. B cell survival and dendritic cells function requires SPPL2A.

  8. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

SPPL2A Protein Profile

Protein Summary

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

Gene names and symbols associated with SPPL2A

  • signal peptide peptidase-like 2A (Sppl2a)
  • signal peptide peptidase-like 2A (RCJMB04_13a21)
  • signal peptide peptidase-like 2A (LOC453430)
  • signal peptide peptidase-like 2A (sppl2a)
  • signal peptide peptidase-like 2A (LOC100231183)
  • signal peptide peptidase-like 2A (LOC100348259)
  • Signal peptide peptidase-like 2A (psl2)
  • signal peptide peptidase like 2A (SPPL2A)
  • signal peptide peptidase like 2A (Sppl2a)
  • 2010106G01Rik protein
  • C130089K23Rik protein
  • IMP3 protein
  • LOC453430 protein
  • LOC100231183 protein
  • PSL2 protein
  • RGD1563001 protein
  • SPPL2A protein

Protein level used designations for SPPL2A

signal peptide peptidase-like 2A , Signal peptide peptidase-like 2A , IMP-3 , SPP-like 2A , intramembrane cleaving protease , intramembrane protease 3 , presenilin-like protein 2 , SPP-like 2A protein , protein SPPL2a

GENE ID SPECIES
311401 Rattus norvegicus
415450 Gallus gallus
453430 Pan troglodytes
100135083 Xenopus (Silurana) tropicalis
100231183 Taeniopygia guttata
100348259 Oryctolagus cuniculus
100380541 Salmo salar
84888 Homo sapiens
66552 Mus musculus
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