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anti-Signal Peptide Peptidase-Like 2B (SPPL2B) Antibodies

SPPL2B encodes a member of the GXGD family of aspartic proteases. Additionally we are shipping SPPL2B Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPPL2B 56928 Q8TCT7
SPPL2B 73218 Q3TD49
SPPL2B 362828 Q5PQL3
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Top anti-SPPL2B Antibodies at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB   50 μL Log in to see 6 to 9 Days
$477.75
Details

SPPL2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


Mouse (Murine)


Rat (Rattus)


More Antibodies against SPPL2B Interaction Partners

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (show HM13 Antibodies) and SPPL3 (show SPPL3 Antibodies) are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 (show TFRC Antibodies) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (show ITM2B Antibodies)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP (show SPEB Antibodies), SPPL2a (show SPPL2A Antibodies), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (show SPEB Antibodies) and SPPL3 (show SPPL3 Antibodies) are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (show TNF Antibodies) into the cytosol.

  6. SPPL2a (show SPPL2A Antibodies) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP (show SPEB Antibodies) nor SPPL3 (show SPPL3 Antibodies) is capable of processing the Bri2 (show ITM2B Antibodies) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (show TNF Antibodies) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a (show SPPL2A Antibodies), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (show CD74 Antibodies) proteolysis in B and dendritic cells

SPPL2B Antigen Profile

Protein Summary

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2) antibody
  • signal peptide peptidase-like 2B (sppl2b) antibody
  • signal peptide peptidase like 2B (sppl2b) antibody
  • signal peptide peptidase like 2B (SPPL2B) antibody
  • signal peptide peptidase like 2B (Sppl2b) antibody
  • signal peptide peptidase-like 2B (SPPL2B) antibody
  • signal peptide peptidase-like 2B (Sppl2b) antibody
  • 3110056O03Rik antibody
  • AW550292 antibody
  • IMP-4 antibody
  • IMP4 antibody
  • MGC147524 antibody
  • PSH4 antibody
  • PSL1 antibody
  • RGD1308556 antibody
  • SPPL2B antibody
  • wu:fc16e01 antibody
  • wu:fc85d12 antibody
  • zgc:136525 antibody

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
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