You are viewing an incomplete version of our website. Please click to reload the website as full version.

Signal Peptide Peptidase-Like 2B (SPPL2B) ELISA Kits

SPPL2B encodes a member of the GXGD family of aspartic proteases. Additionally we are shipping SPPL2B Antibodies (7) and SPPL2B Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SPPL2B SPPL2B 56928 Q8TCT7
Anti-Mouse SPPL2B SPPL2B 73218 Q3TD49
Anti-Rat SPPL2B SPPL2B 362828 Q5PQL3
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

More ELISA Kits for SPPL2B Interaction Partners

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 (show TFRC ELISA Kits) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (show ITM2B ELISA Kits)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (show TNF ELISA Kits) into the cytosol.

  6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B ELISA Kits) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (show TNF ELISA Kits) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (show CD74 ELISA Kits) proteolysis in B and dendritic cells

SPPL2B Antigen Profile

Antigen Summary

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2) antibody
  • signal peptide peptidase-like 2B (sppl2b) antibody
  • signal peptide peptidase like 2B (sppl2b) antibody
  • signal peptide peptidase like 2B (SPPL2B) antibody
  • signal peptide peptidase like 2B (Sppl2b) antibody
  • signal peptide peptidase-like 2B (SPPL2B) antibody
  • signal peptide peptidase-like 2B (Sppl2b) antibody
  • 3110056O03Rik antibody
  • AW550292 antibody
  • IMP-4 antibody
  • IMP4 antibody
  • MGC147524 antibody
  • PSH4 antibody
  • PSL1 antibody
  • RGD1308556 antibody
  • SPPL2B antibody
  • wu:fc16e01 antibody
  • wu:fc85d12 antibody
  • zgc:136525 antibody

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
Did you look for something else?