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Signal Peptide Peptidase-Like 2B Proteins (SPPL2B)

SPPL2B encodes a member of the GXGD family of aspartic proteases. Additionally we are shipping SPPL2B Antibodies (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPPL2B 56928 Q8TCT7
SPPL2B 73218 Q3TD49
Rat SPPL2B SPPL2B 362828 Q5PQL3
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Top SPPL2B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details

SPPL2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Signal Peptide Peptidase-Like 2B (SPPL2B) Interaction Partners

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 (show TFRC Proteins) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (show ITM2B Proteins)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (show TNF Proteins) into the cytosol.

  6. SPPL2a (show SPPL2A Proteins) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B Proteins) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (show TNF Proteins) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a (show SPPL2A Proteins), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (show CD74 Proteins) proteolysis in B and dendritic cells

SPPL2B Protein Profile

Protein Summary

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2)
  • signal peptide peptidase-like 2B (sppl2b)
  • signal peptide peptidase like 2B (sppl2b)
  • signal peptide peptidase like 2B (SPPL2B)
  • signal peptide peptidase like 2B (Sppl2b)
  • signal peptide peptidase-like 2B (SPPL2B)
  • signal peptide peptidase-like 2B (Sppl2b)
  • 3110056O03Rik protein
  • AW550292 protein
  • IMP-4 protein
  • IMP4 protein
  • MGC147524 protein
  • PSH4 protein
  • PSL1 protein
  • RGD1308556 protein
  • SPPL2B protein
  • wu:fc16e01 protein
  • wu:fc85d12 protein
  • zgc:136525 protein

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
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