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SSR4 encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. Additionally we are shipping Signal Sequence Receptor, delta Antibodies (31) and Signal Sequence Receptor, delta Proteins (7) and many more products for this protein.
We now report eight affected males with either de novo (4) or inherited (4) loss of function mutations in SSR4.
results of this study implicate TRAPD as a candidate gene with potential functions that might be associated with ultraviolet-induced melanomagenesis and metastasis
This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.
, signal sequence receptor subunit delta
, translocon-associated protein delta
, translocon-associated protein subunit delta
, signal sequence receptor 4
, signal sequence receptor, delta (translocon-associated protein delta)