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The product of SIPA1 is a mitogen induced GTPase activating protein (GAP). Additionally we are shipping SIPA1 Kits (3) and SIPA1 Proteins (3) and many more products for this protein.
Showing 10 out of 96 products:
Hamster Monoclonal SIPA1 Primary Antibody for IP, WB - ABIN1449260
Weissmann: Molecular genetics of transmissible spongiform encephalopathies. in The Journal of biological chemistry 1999
Show all 7 references for ABIN1449260
Human Monoclonal SIPA1 Primary Antibody for IP, WB - ABIN1449259
Kometani, Aoki, Kawamata, Shinozuka, Era, Taniwaki, Hattori, Minato: Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model. in Cancer research 2006
Show all 7 references for ABIN1449259
Human Polyclonal SIPA1 Primary Antibody for EIA, IF - ABIN1450109
Hattori, Tsukamoto, Nur-e-Kamal, Rubinfeld, Iwai, Kubota, Maruta, Minato: Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. in Molecular and cellular biology 1995
Show all 4 references for ABIN1450109
Human Polyclonal SIPA1 Primary Antibody for EIA, IHC (p) - ABIN401404
Kurachi, Wada, Tsukamoto, Maeda, Kubota, Hattori, Iwai, Minato: Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. in The Journal of biological chemistry 1997
Human Polyclonal SIPA1 Primary Antibody for WB - ABIN2787827
Lee, Nah, Hong, Lee, Jeon, Pak, Huh, Kim, Chae, Kang, Kim, Kim: Spa-1 regulates the maintenance and differentiation of human embryonic stem cells. in The International journal of developmental biology 2007
Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.
The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.
afadin (show MLLT4 Antibodies) regulates the cyclical activation and inactivation of Rap1 (show TERF2IP Antibodies), Rac1, and RhoA (show RHOA Antibodies) through SPA-1 and ARAP1 (show ARAP1 Antibodies).
results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis
Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression.
nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling.
BRD4 (show BRD4 Antibodies) short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors.
Polymorphism in Sipa1 promoter gene is associated with lung cancer.
Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042).
SIPA1 expression is increased in human colorectal cancer.
In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 (show MMP9 Antibodies) after controlling for stage and lymphvascular space invasion.
Data identif a Rap (show LRPAP1 Antibodies) GTPase-activating protein (show RASA1 Antibodies), signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4 (show BRD4 Antibodies).
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
signal-induced proliferation-associated gene 1
, Signal peptidase I (leader peptidase I)
, signal-induced proliferation-associated 1
, signal-induced proliferation-associated protein 1-like
, GTPase-activating protein Spa-1
, signal-induced proliferation-associated protein 1
, p130 SPA-1