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The product of SIPA1 is a mitogen induced GTPase activating protein (GAP). Additionally we are shipping SIPA1 Antibodies (92) and SIPA1 Kits (3) and many more products for this protein.
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Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.
The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.
afadin regulates the cyclical activation and inactivation of Rap1 (show TERF2IP Proteins), Rac1, and RhoA (show RHOA Proteins) through SPA-1 and ARAP1 (show ARAP1 Proteins).
Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression.
nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling.
BRD4 (show BRD4 Proteins) short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors.
Polymorphism in Sipa1 promoter gene is associated with lung cancer.
Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042).
SIPA1 expression is increased in human colorectal cancer.
In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 (show MMP9 Proteins) after controlling for stage and lymphvascular space invasion.
Data identif a Rap (show LRPAP1 Proteins) GTPase-activating protein (show RASA1 Proteins), signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4 (show BRD4 Proteins).
SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
signal-induced proliferation-associated gene 1
, Signal peptidase I (leader peptidase I)
, signal-induced proliferation-associated 1
, signal-induced proliferation-associated protein 1-like
, GTPase-activating protein Spa-1
, signal-induced proliferation-associated protein 1
, p130 SPA-1