You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Signal-Regulatory Protein alpha (SIRPA) Antibodies

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Additionally we are shipping SIRPA Proteins (26) and SIRPA Kits (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SIRPA Antibodies at antibodies-online.com

Showing 10 out of 214 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of SIRP alpha in THP-1 cells with this product at 1 μg/ml. Western blot analysis of SIRP alpha in THP-1 whole cell lysate with this product at 0.5 µg/ml dilution. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Rat Mouse FITC FACS ABIN119468 staining of rat peritoneal macrophages 0.1 mg Log in to see 6 to 8 Days
$632.50
Details
Rat Mouse PE FACS ABIN119470 staining of rat peritoneal macrophages. 100 Tests Log in to see 6 to 8 Days
$643.50
Details
Rat Mouse Un-conjugated FACS, IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$253.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIRPA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of SIRPalpha1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-SIRPalpha1 antibody. Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Rat Mouse Biotin FACS   0.1 mg Log in to see 6 to 8 Days
$308.00
Details
Pig Mouse FITC FACS 0.1 mg Log in to see 6 to 8 Days
$775.50
Details
Human Mouse Un-conjugated FACS, IHC (fro)   0.1 mg Log in to see 6 to 8 Days
$308.00
Details

SIRPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, , ,
,
, , , , ,
Mouse (Murine) , ,
, ,
,
, , , , , , ,
Rat (Rattus) , , , ,
,
,
, , ,

Top referenced anti-SIRPA Antibodies

  1. Pig (Porcine) Monoclonal SIRPA Primary Antibody for FACS - ABIN317417 : Domenech, Rodríguez-Carreño, Filgueira, Alvarez, Chamorro, Domínguez: Identification of porcine macrophages with monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. in Veterinary immunology and immunopathology 2003 (PubMed)
    Show all 10 references for ABIN317417

  2. Mouse (Murine) Monoclonal SIRPA Primary Antibody for IF, WB - ABIN968312 : Adams, van der Laan, Vernon-Wilson, Renardel de Lavalette, Döpp, Dijkstra, Simmons, van den Berg: Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 4 references for ABIN968312

  3. Human Polyclonal SIRPA Primary Antibody for EIA, IF - ABIN500722 : Kharitonenkov, Chen, Sures, Wang, Schilling, Ullrich: A family of proteins that inhibit signalling through tyrosine kinase receptors. in Nature 1997 (PubMed)
    Show all 4 references for ABIN500722

  4. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS - ABIN120468 : Barclay: The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. in Immunology 1981 (PubMed)
    Show all 3 references for ABIN120468

  5. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS, IHC (fro) - ABIN120471 : Robinson, White, Mason: Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. in Immunology 1986 (PubMed)
    Show all 3 references for ABIN120471

  6. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS - ABIN119470 : Damoiseaux, Döpp, Neefjes, Beelen, Dijkstra: Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18). in Journal of leukocyte biology 1989 (PubMed)
    Show all 3 references for ABIN119470

  7. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS - ABIN119468 : Damoiseaux, Döpp, Beelen, Dijkstra: Rat bone marrow and monocyte cultures: influence of culture time and lymphokines on the expression of macrophage differentiation antigens. in Journal of leukocyte biology 1989 (PubMed)
    Show all 3 references for ABIN119468

  8. Human Monoclonal SIRPA Primary Antibody for FACS, IHC (fro) - ABIN316959 : Fujioka, Matozaki, Noguchi, Iwamatsu, Yamao, Takahashi, Tsuda, Takada, Kasuga: A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. in Molecular and cellular biology 1997 (PubMed)
    Show all 2 references for ABIN316959

  9. Cow (Bovine) Polyclonal SIRPA Primary Antibody for WB - ABIN2792091 : Kong, Yan, Chen, Dong, Yang, Liu, Yu, Huang, Liu, Liu, Wu, Wang: LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages. in The Journal of experimental medicine 2007 (PubMed)

More Antibodies against SIRPA Interaction Partners

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. Data suggest a reduction in the CD47 antigen (show CD47 Antibodies)/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Antibodies)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  2. agents that block the CD47 (show CD47 Antibodies):SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  3. the data suggest that combinatorial actions of ADAM10 (show ADAM10 Antibodies) and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  4. Loss of cell surface CD47 (show CD47 Antibodies) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  5. Velcro" engineering of high affinity CD47 (show CD47 Antibodies) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  6. Combinatorial expression of NKX2-5 (show NKX2-5 Antibodies), SIRPA, VCAM1 (show VCAM1 Antibodies) and CD34 (show CD34 Antibodies) can be used to define discrete stages of cardiovascular cell lineage differentiation.

  7. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG (show SIRPG Antibodies).

  8. These results suggest that thrombospondin-1 (show THBS1 Antibodies) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (show NOX1 Antibodies), limits vasodilation, and promotes renal ischemia reperfusion injury.

  9. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 (show CD47 Antibodies) and initiate intracellular signaling

  10. Polymorphisms in the human inhibitory signal-regulatory protein alpha do not affect binding to its ligand CD47 (show CD47 Antibodies).

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. SIRPalpha intrinsic to CD11c (show ITGAX Antibodies)(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  2. Loss of cell surface CD47 (show CD47 Antibodies) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  3. Velcro" engineering of high affinity CD47 (show CD47 Antibodies) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  4. Polymorphism in the innate immune receptor SIRPalpha controls CD47 (show CD47 Antibodies) binding and autoimmunity in the nonobese diabetic mouse.

  5. These data show a previously unappreciated and crucial role for SIRPalpha in the homeostasis of CD103 (show ITGAE Antibodies)(+) CD11b (show ITGAM Antibodies)(+) DCs in the intestine

  6. These results suggest that thrombospondin-1 (show THBS1 Antibodies) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (show NOX1 Antibodies), limits vasodilation, and promotes renal ischemia reperfusion injury.

  7. sought to investigate the effect of Hsp70 (show HSP70 Antibodies)-peptide complex on the expression of CD172alpha and CD47 (show CD47 Antibodies) receptors in normal peritoneal macrophages (NMO)

  8. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 (show CD47 Antibodies) and initiate intracellular signaling

  9. Studies suggest that the mouse strain effect on xenogeneic engraftment might be ascribed mainly to the binding affinity of strain-specific polymorphic SIRPA with human CD47 (show CD47 Antibodies).

  10. SIRPA plays a protective role in cardiac hypertrophy through negative regulation of the Toll-like receptor 4 (show TLR4 Antibodies)/nuclear factor-kappaB pathway.

SIRPA Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal-regulatory protein alpha (SIRPA) antibody
  • signal-regulatory protein beta 1 (SIRPB1) antibody
  • signal-regulatory protein alpha (Sirpa) antibody
  • AI835480 antibody
  • Bit antibody
  • CD172a antibody
  • MFR antibody
  • MYD-1 antibody
  • P84 antibody
  • Ptpns1 antibody
  • SHP-1 antibody
  • SHPS-1 antibody
  • SHPS1 antibody
  • SIRP antibody
  • SIRP-A1 antibody
  • SIRP-B1 antibody
  • SIRPA antibody
  • swc3 antibody

Protein level used designations for SIRPA

signal-regulatory protein alpha , protein tyrosine phosphatase, non-receptor type substrate 1 , MyD-1 antigen , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , SHP substrate 1 , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , signal-regulatory protein alpha-1 , sirp-alpha-1 , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen , SHPS-1

GENE ID SPECIES
419267 Gallus gallus
458039 Pan troglodytes
529990 Bos taurus
609452 Canis lupus familiaris
717811 Macaca mulatta
771734 Gallus gallus
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
140885 Homo sapiens
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
327666 Bos taurus
Selected quality suppliers for anti-SIRPA (SIRPA) Antibodies
Did you look for something else?