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Signal-Regulatory Protein alpha Proteins (SIRPA)

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Additionally we are shipping SIRPA Antibodies (214) and SIRPA Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Top SIRPA Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$563.20
Details
HOST_HEK-293 Human Un-conjugated Human recombinant CD172A / SIRP. The purity of rh CD 172a/SIRPA was determined by DTT-reduced (+) SDSPAGE and staining overnight with Coomasste Blue. 50 μg Log in to see 2 to 3 Days
$630.00
Details

SIRPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , ,
Mouse (Murine) , ,
, , ,
Rat (Rattus) ,

Top referenced SIRPA Proteins

  1. Human SIRPA Protein expressed in Human Cells - ABIN2004433 : Timms, Swanson, Marie-Cardine, Raab, Rudd, Schraven, Neel: SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. in Current biology : CB 1999 (PubMed)
    Show all 4 references for ABIN2004433

  2. Rat (Rattus) SIRPA Protein expressed in Human Cells - ABIN2009407 : Stofega, Argetsinger, Wang, Ullrich, Carter-Su: Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 references for ABIN2009407

  3. Mouse (Murine) SIRPA Protein expressed in Human Cells - ABIN2008444 : Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. in Journal of proteome research 2005 (PubMed)
    Show all 4 references for ABIN2008444

More Proteins for Signal-Regulatory Protein alpha (SIRPA) Interaction Partners

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. Data suggest a reduction in the CD47 antigen (show CD47 Proteins)/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Proteins)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  2. agents that block the CD47 (show CD47 Proteins):SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  3. the data suggest that combinatorial actions of ADAM10 (show ADAM10 Proteins) and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  4. Loss of cell surface CD47 (show CD47 Proteins) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  5. Velcro" engineering of high affinity CD47 (show CD47 Proteins) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  6. Combinatorial expression of NKX2-5 (show NKX2-5 Proteins), SIRPA, VCAM1 (show VCAM1 Proteins) and CD34 (show CD34 Proteins) can be used to define discrete stages of cardiovascular cell lineage differentiation.

  7. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG (show SIRPG Proteins).

  8. These results suggest that thrombospondin-1 (show THBS1 Proteins) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (show NOX1 Proteins), limits vasodilation, and promotes renal ischemia reperfusion injury.

  9. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 (show CD47 Proteins) and initiate intracellular signaling

  10. Polymorphisms in the human inhibitory signal-regulatory protein alpha do not affect binding to its ligand CD47 (show CD47 Proteins).

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. SIRPalpha intrinsic to CD11c (show ITGAX Proteins)(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  2. Loss of cell surface CD47 (show CD47 Proteins) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  3. Velcro" engineering of high affinity CD47 (show CD47 Proteins) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  4. Polymorphism in the innate immune receptor SIRPalpha controls CD47 (show CD47 Proteins) binding and autoimmunity in the nonobese diabetic mouse.

  5. These data show a previously unappreciated and crucial role for SIRPalpha in the homeostasis of CD103 (show ITGAE Proteins)(+) CD11b (show ITGAM Proteins)(+) DCs in the intestine

  6. These results suggest that thrombospondin-1 (show THBS1 Proteins) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (show NOX1 Proteins), limits vasodilation, and promotes renal ischemia reperfusion injury.

  7. sought to investigate the effect of Hsp70 (show HSP70 Proteins)-peptide complex on the expression of CD172alpha and CD47 (show CD47 Proteins) receptors in normal peritoneal macrophages (NMO)

  8. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 (show CD47 Proteins) and initiate intracellular signaling

  9. Studies suggest that the mouse strain effect on xenogeneic engraftment might be ascribed mainly to the binding affinity of strain-specific polymorphic SIRPA with human CD47 (show CD47 Proteins).

  10. SIRPA plays a protective role in cardiac hypertrophy through negative regulation of the Toll-like receptor 4 (show TLR4 Proteins)/nuclear factor-kappaB pathway.

SIRPA Protein Profile

Protein Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal-regulatory protein alpha (SIRPA)
  • signal-regulatory protein beta 1 (SIRPB1)
  • signal-regulatory protein alpha (Sirpa)
  • AI835480 protein
  • Bit protein
  • CD172a protein
  • MFR protein
  • MYD-1 protein
  • P84 protein
  • Ptpns1 protein
  • SHP-1 protein
  • SHPS-1 protein
  • SHPS1 protein
  • SIRP protein
  • SIRP-A1 protein
  • SIRP-B1 protein
  • SIRPA protein
  • swc3 protein

Protein level used designations for SIRPA

signal-regulatory protein alpha , protein tyrosine phosphatase, non-receptor type substrate 1 , MyD-1 antigen , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , SHP substrate 1 , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , signal-regulatory protein alpha-1 , sirp-alpha-1 , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen , SHPS-1

GENE ID SPECIES
419267 Gallus gallus
458039 Pan troglodytes
529990 Bos taurus
609452 Canis lupus familiaris
717811 Macaca mulatta
771734 Gallus gallus
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
140885 Homo sapiens
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
327666 Bos taurus
Selected quality suppliers for SIRPA Proteins (SIRPA)
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