anti-Signal-Regulatory Protein alpha (SIRPA) Antibodies

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Additionally we are shipping SIRPA Proteins (32) and SIRPA Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Top anti-SIRPA Antibodies at antibodies-online.com

Showing 10 out of 218 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SIRPA Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Rat Mouse FITC FACS ABIN119468 staining of rat peritoneal macrophages 0.1 mg Log in to see 6 to 8 Days
$632.50
Details
Rat Mouse PE FACS ABIN119470 staining of rat peritoneal macrophages. 100 Tests Log in to see 6 to 8 Days
$643.50
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of SIRPalpha1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-SIRPalpha1 antibody. Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2). 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Pig Mouse FITC FACS 0.1 mg Log in to see 6 to 8 Days
$775.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells, using Sirp alpha1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Sirp alpha1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details
Rat Mouse Un-conjugated FACS, IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$253.00
Details
Human Rabbit Un-conjugated IP, ELISA 100 μg Log in to see 20 to 21 Days
$218.90
Details

SIRPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIRPA Antibodies

  1. Mouse (Murine) Monoclonal SIRPA Primary Antibody for BR, FACS - ABIN2689017 : Chuang, Lagenaur: Central nervous system antigen P84 can serve as a substrate for neurite outgrowth. in Developmental biology 1990 (PubMed)
    Show all 7 Pubmed References

  2. Mouse (Murine) Monoclonal SIRPA Primary Antibody for IF, WB - ABIN968312 : Adams, van der Laan, Vernon-Wilson, Renardel de Lavalette, Döpp, Dijkstra, Simmons, van den Berg: Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 4 Pubmed References

  3. Cow (Bovine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478782 : : Epoetin--an important advance. in Drug and therapeutics bulletin 1992 (PubMed)
    Show all 4 Pubmed References

  4. Cow (Bovine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478783 : Howard, Brooke, Werling, Sopp, Hope, Parsons, Collins: Dendritic cells in cattle: phenotype and function. in Veterinary immunology and immunopathology 2000 (PubMed)
    Show all 4 Pubmed References

  5. Rat (Rattus) Monoclonal SIRPA Primary Antibody for FACS, IHC (fro) - ABIN260107 : Lazo, Klein-Szanto, Tsichlis: T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. in Journal of virology 1990 (PubMed)
    Show all 3 Pubmed References

  6. Pig (Porcine) Monoclonal SIRPA Primary Antibody for IHC (fro), FACS - ABIN2478796 : Dutkiewicz, Stepie?, Witeska: [Diagnostic value of prostatic specific antigen (PSA) in comparison to prostatic acid phosphatase (PAP) in prostatic cancer and adenoma]. in Wiadomo?ci lekarskie (Warsaw, Poland : 1960) 1993 (PubMed)
    Show all 4 Pubmed References

  7. Pig (Porcine) Monoclonal SIRPA Primary Antibody for FACS - ABIN2478797 : Bullido, Pérez de la Lastra, Almazán, Ezquerra, Llanes, Alonso, Domínguez: Induction of aggregation in porcine lymphoid cells by antibodies to CD46. in Veterinary immunology and immunopathology 2000 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal SIRPA Primary Antibody for IHC (fro), FACS - ABIN2478785 : Murray: A field investigation of causes of abortion in dairy cattle. in The Veterinary record 1991 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal SIRPA Primary Antibody for FACS - ABIN2478791 : Fujioka, Matozaki, Noguchi, Iwamatsu, Yamao, Takahashi, Tsuda, Takada, Kasuga: A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. in Molecular and cellular biology 1997 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal SIRPA Primary Antibody for FACS - ABIN2478787 : van Beek, Cochrane, Barclay, van den Berg: Signal regulatory proteins in the immune system. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 3 Pubmed References

More Antibodies against SIRPA Interaction Partners

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. CD47 (show CD47 Antibodies), TSP1 (show THBS1 Antibodies), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  2. exploited by Hepatitis E virus to negative regulated IFN-beta (show IFNB1 Antibodies) of the host innate immune system to promote viral infection

  3. Data suggest a reduction in the CD47 antigen (show CD47 Antibodies)/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Antibodies)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  4. agents that block the CD47 (show CD47 Antibodies):SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  5. the data suggest that combinatorial actions of ADAM10 (show ADAM10 Antibodies) and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  6. Loss of cell surface CD47 (show CD47 Antibodies) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  7. Velcro" engineering of high affinity CD47 (show CD47 Antibodies) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  8. Combinatorial expression of NKX2-5 (show NKX2-5 Antibodies), SIRPA, VCAM1 (show VCAM1 Antibodies) and CD34 (show CD34 Antibodies) can be used to define discrete stages of cardiovascular cell lineage differentiation.

  9. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG (show SIRPG Antibodies).

  10. These results suggest that thrombospondin-1 (show THBS1 Antibodies) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (show NOX1 Antibodies), limits vasodilation, and promotes renal ischemia reperfusion injury.

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47 (show CD47 Antibodies)-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  2. Data provide evidence that SIRPalpha-mediated phagocytosis is not a major determinant in prion (show PRNP Antibodies) disease pathogenesis.

  3. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47 (show CD47 Antibodies)-SIRPA interaction and Rac1/Akt (show AKT1 Antibodies) activation.

  4. In conclusion, our data suggest that SIRPalpha signaling through SHP-2 (show PTPN11 Antibodies)-PI3K-Akt2 (show AKT2 Antibodies) strongly influences osteoblast differentiation from bone marrow stromal cells.

  5. These results indicate an important role for CD47 (show CD47 Antibodies)-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.

  6. TLR5 (show TLR5 Antibodies) mediates CD172a(+) intestinal lamina propria dendritic cell induction of Th17 cells.

  7. SIRPalpha intrinsic to CD11c (show ITGAX Antibodies)(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  8. Loss of cell surface CD47 (show CD47 Antibodies) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  9. Velcro" engineering of high affinity CD47 (show CD47 Antibodies) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  10. Polymorphism in the innate immune receptor SIRPalpha controls CD47 (show CD47 Antibodies) binding and autoimmunity in the nonobese diabetic mouse.

SIRPA Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal-regulatory protein alpha (SIRPA) antibody
  • signal-regulatory protein beta 1 (SIRPB1) antibody
  • signal-regulatory protein alpha (Sirpa) antibody
  • AI835480 antibody
  • Bit antibody
  • CD172a antibody
  • MFR antibody
  • MYD-1 antibody
  • P84 antibody
  • Ptpns1 antibody
  • SHP-1 antibody
  • SHPS-1 antibody
  • SHPS1 antibody
  • SIRP antibody
  • SIRP-A1 antibody
  • SIRP-B1 antibody
  • SIRPA antibody
  • swc3 antibody

Protein level used designations for SIRPA

signal-regulatory protein alpha , protein tyrosine phosphatase, non-receptor type substrate 1 , MyD-1 antigen , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , SHP substrate 1 , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , signal-regulatory protein alpha-1 , sirp-alpha-1 , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen , SHPS-1

GENE ID SPECIES
419267 Gallus gallus
458039 Pan troglodytes
529990 Bos taurus
609452 Canis lupus familiaris
717811 Macaca mulatta
771734 Gallus gallus
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
140885 Homo sapiens
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
327666 Bos taurus
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