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SAP130 is a subunit of the histone deacetylase (see HDAC1\; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008].. Additionally we are shipping and SAP130 Kits (1) and many more products for this protein.
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Human Polyclonal SAP130 Primary Antibody for EIA, WB - ABIN954668
Truty, Lomberk, Fernandez-Zapico, Urrutia: Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. in The Journal of biological chemistry 2009
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the TGFbeta (show TGFB1 Antibodies) pathway activation leads to recruitment of a KLF14 (show SP6 Antibodies)-mSin3A-HDAC2 (show HDAC2 Antibodies) repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.
SAP130 is a subunit of the histone deacetylase (see HDAC1\; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003
Sin3A associated protein 130
, histone deacetylase complex subunit SAP130
, Sin3A-associated protein, 130kDa
, potential spliceosomal U2 snRNP complex SF3b component
, histone deacetylase complex subunit SAP130-like
, 130 kDa Sin3-associated polypeptide
, Sin3A associated protein, 130kDa
, sin3-associated polypeptide p130
, Sin3-associated polypeptide p130
, mSin3A-associated protein 130