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May be involved in visual system development..
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Zebrafish Polyclonal SIX3 Primary Antibody for ELISA, WB - ABIN334491
Ando, Kobayashi, Tsubokawa, Uyemura, Furuta, Okamoto: Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. in Developmental biology 2005
Lhx2 (show LHX2 Antibodies) may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3b.
lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS.
SIX3 and SIX6 (show SIX6 Antibodies) play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.
Sox2 directly activates the Six3 forebrain enhancer.
Six3OS regulates Six3 activity in developing retina by a mechanism via which promoter-associated long non-coding RNAs can modulate the activity of their associated protein coding genes during development.
It was shown that Six3 is necessary for ependymal cell maturation during postnatal stages of brain development. In its absence, ependymal cells fail to suppress radial glia characteristics.
Neuroretina specification requires Six3-mediated suppression of Wnt8b (show WNT8B Antibodies) a few hours later at the 6- to 8-somite stage.
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
role of expression with pax6 (show PAX6 Antibodies) on haploinsufficient lens phenotype
Six 3 and Six 6 (show SIX6 Antibodies) are differentially required during forebrain development; gene expression in brain
The Pax (show PXN Antibodies)-Eya-Six-Dach (show DACH1 Antibodies) network is at best only partly conserved during lens and nasal placode development.
Six3 directly activates Pax6 and probably also Sox2 in the PLE and regulates cell autonomously the earliest stages of mammalian lens induction.
May be involved in visual system development.
sine oculis homeobox homolog 6
, homeobox protein SIX3
, sine oculis homeobox homolog 3
, sine oculis-related homeobox 3 homolog